Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of artichoke extract powder in China. Please feel free to wholesale high quality artichoke extract powder for sale here from our factory. For price consultation, contact us.
Artichoke Extract powder supplier/Manufacturer - kintaibio®
Kintaibio® Artichoke Extract is made from artichoke leaves (Cynara scolymus L.), which have higher levels of polyphenols and flavonoids than other parts of the plant. The leaves contain 2.97 times more polyphenols and 2.65 times more flavonoids than pedicels, and 2.13 times and 2.00 times more than flower buds, respectively. These leaves are rich in caffeoylquinic acid compounds, like chlorogenic acid and cynarin, ensuring the extract's high bioactivity.
Using PLC-DAD-ESI/MS/MS, we have qualitatively identified up to 27 polyphenols from the leaves. To ensure batch-to-batch consistency and predictable results, we rigorously standardize our core active ingredients and offer the following specifications:
- Cynarin standardized to 2.5% - 5% (w/w)
- Chlorogenic Acid standardized to 5% - 10% (w/w)
- Total polyphenol content ≥ 2.5% (calculated as cynarin according to the European Pharmacopoeia method)
Artichoke Extract powder Production Process
We utilize an ethyl acetate extraction process optimized through orthogonal experiments to efficiently enrich the target active ingredient, specifically cynarin. After systematic parameter screening and validation, we determined the following optimal extraction parameters, achieving a balance between yield and efficiency:
- Extraction time: 30 minutes
- Phase separation time: 80 minutes
- Extract concentration: 10.0 g/L
- Phase ratio (solvent ratio): 1.25:1
- Extraction temperature: 35°C
- pH: 4.0
Under these optimized conditions, a cynarin extraction yield of 67.37% was achieved. This process is stable and controllable, providing reliable support for large-scale production of high-quality extracts.
kintaibio® Artichoke Extract powder Quality Control and Testing Methods
We have established a comprehensive quality control system and utilize relevant technologies to ensure that our product quality meets your needs.
1. Qualitative Identification: HPTLC is used as a rapid and accurate method to ensure the presence of the hallmark ingredients chlorogenic acid and luteolin-7-glucoside.
2. Assay: UPLC and HPLC are used to accurately quantify chlorogenic acid and cynarin, respectively.
Our analytical methods demonstrate excellent linearity and reliable recoveries (e.g., an average recovery of 99.10% for chlorogenic acid). The results are accurate and highly reproducible, providing solid technical support for raw material procurement and finished product quality control.
2.1 Assay of Chlorogenic Acid: We have established a UPLC method. This method, using an Acquity BEH C18 column (2.1 mm × 100 mm, 1.7 μm), demonstrated excellent linearity over the concentration range of 0.013 to 1.3 mg/mL, with an average recovery of 99.10% (RSD = 1.87%). This method offers the advantages of rapid analysis, minimal solvent consumption, and accurate results, making it suitable for rapid quality control.
2.2 Assay of cynarin: We employed high-performance liquid chromatography (HPLC) for precise quantification. Using a Waters Symmetry C-18 column, this method demonstrated excellent linearity (r = 0.9994) over the concentration range of 38 μg/mL to 190 μg/mL, with average recoveries ranging from 97.4% to 102.3% (RSD = 3.0%). This method is simple to operate, offers accurate and reproducible results, and effectively guides raw material procurement and finished product quality control.
Pre-COA of Artichoke Leaf Extract
benefits of Artichoke Leaf Extract
1. Antioxidant Effect
Artichoke extract, like vitamin C, vitamin E, N,N-diphenyl-p-phenylenediamine, hydroxyphenylacrylic acid, and flavonoids, possesses strong antioxidant capacity, scavenging free radicals, inhibiting oxidative stress, and low-density lipoprotein oxidation. This antioxidant capacity is primarily derived from its polyphenolic components (such as chlorogenic acid and 1,5-dicaffeoylquinic acid).
Researchers used the DCFH-DA (2′,7′-dichlodihydrorofluorescein diacetate) probe to examine the antioxidant capacity of artichoke extract and its major monomeric polyphenols in the human intestinal cell line HT-29. The results revealed that chlorogenic acid and 1,5-dicaffeoylquinic acid are the main antioxidant components in artichoke, and that the antioxidant capacity of artichoke extract is higher than that of the monomeric polyphenols.
2. Effects on the Digestive System
In Europe, artichoke leaf extract is a traditional folk remedy for indigestion and liver protection. In clinical trials, artichoke extract has been shown to significantly improve functional dyspepsia symptoms by promoting bile secretion. Bile acids stimulate glucagon-like peptide-1 in the colon, enhancing insulin secretion and carbohydrate and fat metabolism, without any side effects. Clinical studies have shown a significant increase in bile flow after acute artichoke leaf extract treatment and repeated administration. In vitro studies have also shown that artichoke leaf extract increases bile secretion in rat liver perfusion and hepatocyte culture, demonstrating a good safety profile.
3. Effects on the Cardiovascular System
Since the 1970s, scientists have been studying the effects of cynarin on cholesterol. It has now been demonstrated that artichoke leaf extract regulates lipid metabolism in humans by inhibiting the biosynthesis of cholesterol and endogenous triglycerides, with luteolin playing a particularly important role. Researchers have found that a daily intake of 2-3 g of artichoke leaf extract can reduce low-density lipoprotein (LDL) concentrations by 8-49 mg/dL, total cholesterol by 12-55 mg/dL, and triglycerides by 11-51 mg/dL. Luteolin and chlorogenic acid may play a key role in the lipid-modulating effects of artichoke leaf extract. Artichoke may provide a promising nutritional pathway to reduce the formation of choline-induced atherogenic trimethylamine, ultimately providing cardioprotection in the elderly by inhibiting the formation of trimethylamine oxide.
4. Natural Antimicrobial Properties
Extracts of artichoke in solvents of varying polarity exhibited antimicrobial effects against bacteria, yeasts, and molds. The main antimicrobial components were polyphenolic compounds such as chlorogenic acid and cynarin. An n-butanol extract of artichoke exhibited strong antimicrobial activity against bacteria, yeasts, and molds. The ethanol extracts of artichoke bracts and buds have a minimum antibacterial concentration of 0.08-0.77 mg/mL against seven foodborne bacteria and a minimum antibacterial concentration of 0.87-4.16 mg/mL against eight mycotoxin-producing fungi. The minimum antibacterial concentrations of artichoke bract ethanol extracts against different bacteria and fungi are generally lower than those of bud ethanol extracts, which is consistent with the content of polyphenols in bracts and buds.
The methanol extract of artichoke leaves has different inhibitory effects on different bacteria, and the antibacterial effect of purified polyphenols is significantly enhanced. The antibacterial efficacy of the extract is directly related to the polyphenol content, and the effect of the purified polyphenols is more significant.
Artichoke Leaf Extract Safety
Artichoke leaf extract is generally considered safe for most individuals when consumed in appropriate amounts. However, it may cause mild side effects such as gastrointestinal discomfort in some cases. It is advisable for pregnant and breastfeeding women, as well as those with gallbladder issues or allergies to Asteraceae family plants, to seek medical advice before using artichoke leaf extract.
why choose kintaibio® Artichoke Leaf Extract powder
Our artichoke leaf extract powder is a fine yellow to brown powder with excellent solubility. As your trusted global B2B partner, Kintaibio offers packaging options ranging from 25 kg, 50 kg, and larger, to fully customized packaging. We provide comprehensive GMP and ISO certifications, adhering to strict international quality assurance protocols. We look forward to becoming a reliable link in your supply chain with our superior ingredients and professional service, and working with you to create a new chapter in health products.
We believe Kintaibio's artichoke extract is an ideal ingredient for developing functional foods, dietary supplements, and even pharmaceuticals for digestive health, liver support, cardiovascular health, and antioxidant applications. Please contact sales@kintaibio.com for more technical information and collaboration details.
If you want to purchase high-quality Artichoke Extract Powder, please feel free to contact us at Sales@Kintaibio.Com or provide feedback on the next page. Site web: www.kintai-bio.com
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