Forskohlii Root Extract

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KINTAI is committed to be your best Forskohlii Root Extract supplier. It is the most potent known activator of adenylate cyclase, which can directly stimulate adenylate cyclase, increase the concentration of cyclic adenylate in various tissues and cells, and thus participate in the regulation of various cell functions. It is also an integral part of the process of forming important hormones in the body.

The role of foscoline can lower blood pressure, inhibit allergic reactions and promote thyroxine secretion. Other effects of foscoline are also important, including inhibition of platelet activating factor (PAF) 6-induced inflammation and inhibition of cancer cell proliferation.

[Basic source] Coleus forskohlii (Willd.) Briq.
[Plant form] It is a perennial root and semi-succulent herb. About 40cm high. Stems stout, branched, villous, with denser hairs on the upper part. The leaves are subsuculent, ovate, 7.5-13 cm long, obtuse or pointed apex, base broadly wedge-shaped, gradually tapering, crenate, both surfaces densely covered with villous hairs; petiole about 1.5 cm or less. 6-flowered whorls, forming a raceme, up to 11 cm long; bracts sessile, broadly ovate, membranous, ciliate, tail tip, sparsely covered with glandular puberulous tips, detaching when flowering. Calyx bell-shaped, c. 6 mm long, densely villous, throat densely villous, posterior teeth cordate, remaining teeth subulate-lanceolate, lateral teeth shorter; corolla blue-violet, 1.2-1.5 cm long, slightly glandular, curved, throat dilated, upper lip with 4 unequal lobes, lower lip oblong, concave; stamens slightly projecting or hidden, filaments connate below the middle. 【Medicinal part】root or whole plant.

[Habitat distribution] It grows on the hillside at an altitude of 2300 meters, on the wild side where the land is extremely degraded. It is distributed in India, Sri Lanka, Nepal, Bhutan and tropical Africa.
[Culture] Wild Coleus forskohlii domestic resources are extremely rare in my country. Its range is narrow, mainly in Yunnan and Guizhou, but through hard work it has been successfully cultivated in Yunnan and Hubei. There are some differences between wild varieties and cultivated varieties.
[Ecological characteristics] It has the ecological characteristics of sun-loving, drought-tolerant and poverty-tolerant.
[Origin] Produced in northeast Yunnan, China. Yunnan endemic medicinal plants.

Security Statement: (Europe) 24/25

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Customs code: 2929909090

Figure 2. The UV spectrum of forskolin. 

Figure 3. LC/MS chromatogram and mass spectrum of forskolin in standard stock solution and product extracts. 

1. Reduce intraocular pressure
Studies have pointed out that the basic pharmacological and clinical anti-glaucoma studies of the three forskolin analogs, isoforskolin, deacetylforskolin and 1-acetyl-forskolin isolated from Coleus forskolin, have shown that these three compounds have the activity to activate cyclic AMP in vitro, and can reduce normal intraocular pressure or inhibit elevated intraocular pressure of water load to varying degrees, and it is assumed that 1-acetylforksolin has activity after in vivo metabolism.

2. Asthma and antispasmodic effect
Ethyl acetate extract of Coleus forskohlii has potent antiasthmatic and antispasmodic effects, and antiasthmatic pharmacodynamics and acute toxicity experiences have been analyzed and evaluated. The results show that its antispasmodic power is 145 times higher than that of aminophylline, while its toxicity is much lower than that of aminophylline.

3. Lower Blood Pressure
Coleus forskohlii extract 1-acetoxyforskolin and isofuskolin can effectively lower blood pressure, and the effect is rapid and long-lasting, showing a dose-dependent relationship, while there is no significant effect or statistical effect on heart rate and other parameters. No significant difference. However, compared to currently widely used first-line clinical antihypertensives, it should be checked whether it has more advantages.

4. Inhibition of platelet aggregation
Iveskolin can inhibit ADP, and the inhibitory effect has no obvious selectivity on the three platelet activation pathways. Its mechanism of action may be related to direct activation of adenylate cyclase by Isofaskolin and increased cAMP levels in platelets. Its anticoagulant effect and its hemorrhagic risk must be further evaluated and investigated.

5. Anti-tumor effect
Forskohlii Root Extract has significant anti-tumor activity. According to reports, research on its anti-tumor effect has focused on Forskolin, and similar effects of other ingredients have not been reported. Forskolin can significantly increase cellular adenylyl cyclase activity and cAMP accumulation, and maintaining cAMP level can effectively regulate cell proliferation and differentiation.

Application

1. Application history
It has a long history of use. It is decocted and taken by the Indian folks to treat colds, coughs and respiratory diseases.
2. Modern clinical application
(1) Treatment of asthma and acute and chronic bronchitis： The compound granule made from Coleus forskohlii combined with Peucedanum and licorice is used to treat asthma and bronchitis, and has a good curative effect; in addition, it has a good antipyretic effect on There was no significant effect on important organs and the blood system, and no serious adverse reactions. The compound sheath stamen granules made from Coleus forskohlii as the monarch drug was used for clinical research in the treatment of children with bronchial asthma. It was found that after one A week of application of this product, the concentration of cAMP in plasma increased significantly, with a statistically significant difference, and was highly effective. Low toxicity, cough and asthma relief, effective medicine for the treatment of asthma.

(2) Treatment of Pulmonary Heat. Coleus forskohlii combined with Peucedanum, almond and other traditional Chinese medicines in the treatment of 35 cases of acute lung-heat syndrome were studied. The results showed that , its therapeutic effective rate is 91.43%, Better than that of the control group, and it also has a certain curative effect on acute bronchitis and asthma, indicating that the compound preparation has a good curative effect on lung diseases.

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