Cnidium Monnieri Fruit Extract

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1.1 Introduction

Cnidium monnieri fruit extract is extracted from the fruit of the plant Cnidium Fructus Cnidii, and its active ingredients include pinene, bornyl isovalarate, osthol, dihydroeoserveol, and bergamot Lactone (berapten), osthole (cnidiadin), isopimpinellin, etc.
The efficacy and function of Cnidium Fructus Extract are very comprehensive, which are specifically reflected in the following points. First, the Cnidinia Fructus Extract can kill insects and relieve itching, and can improve the erosion problem of sexual vagina. Can improve the problem of eczema itching. On the second aspect, the extract of Cnidium Fructus Cnidii has a very good effect of warming the kidney and nourishing yang, and can improve kidney deficiency or sexual dysfunction caused by kidney deficiency.

1.2 Source plant

Cnidium monnieri (scientific name: Cnidium monnieri (L.) Cuss.) is an annual herbaceous plant of the genus Cnidium in the family Umbelliferae, with a height of up to 60 cm. Root conical, slender. Stem erect or oblique, much branched, hollow, surface with deep ribs, rough. Leaf sheaths are short and wide, with membranous margins, and the upper petiole is sheath-shaped; the outline of the blade is ovate to triangular-ovate, the outline of the pinna is ovate-ovate-lanceolate, the apex is often slightly caudate, and the last lobes are linear to linear lanceolate, with a small pointed tip, rough on the edge and veins. Compound umbels; involucral bracts, linear to linear-lanceolate, membranous at the margin, with thin eyelashes; umbrella rays of unequal length, rough on the edges; numerous involucral bracts, linear, small umbels with flowers, Calyx teeth absent; petals white, with inflexed ligules at apex; stylopodium slightly raised, style recurved downward. The meridians are oblong, nearly pentagonal in cross section, bloom from April to July, and bear fruit from June to October.

Distributed in East China, Central South, Southwest, Northwest, North China, Northeast China; Russia, North Korea, Vietnam, North America and other European countries are also distributed. It grows in fields, roadsides, meadows and riverside wetlands.

The fruit of Cnidium Cnidium is used as medicine, which has the effects of drying dampness, killing insects, relieving itching, strengthening yang, and treating skin eczema, vaginal trichomoniasis, kidney deficiency and impotence. Because the leaves of Cnidium are beautiful, pinnately divided, and the inflorescences are pure white and fragrant, they can be used as landscaping plants to beautify the living environment.

1.3 Chemical composition

The main components are pinene, camphene, bornyl isovalerate, and isoborneol. It also contains methoxyparscreol, ostidin, iso-saxifragein, bergamot lactone, dihydro-kaeverol and its angelic acid ester, acetate and isovaleric acid ester, ostidine, iso-saxifrage Butyryloxydihydrobesevolyl acetate. The root contains ostidin, isosaxifrage, alloparsin B, xanthoxylin, and parsley.

4.1 Health Benefits

According to the latest pharmacological experiments,Cnidium monnieri fruit extract has the following effects on health:

(1). Anti-trichomonas effect

For traditional Chinese medicine, Cnidium Fructus Extract is a Chinese herbal medicine for treating trichomonas vaginitis. The unique osthole and other substances in the extract of Cnidium Fructus have significant anti-trichomonad properties. By matching with other herbs, they form compound Cnidium Fructus suppositories or lotions, which have a very good effect on trichomonal vaginitis.

(2). Relieving asthma and eliminating phlegm

Total coumarin is an important component of cnidium extract. Its main curative effect is to relieve asthma. For asthmatic patients, total coumarin can effectively reduce lung wheezing. Its main principle of action is: total coumarin can stimulate the expansion of bronchial smooth muscle, reduce the excitability of the smooth muscle contractile protein system, relax the muscle, and thus improve the ventilation function of the lungs.

(3). Taking orally to warm kidney and strengthen yang

In the theory of traditional Chinese medicine, the nature and flavor of cnidium belong to warm meridian, while pungent and bitter belong to kidney meridian. Made into Cnidium Fructus Soup or Cnidium Fructus Kushen Wine, it can warm kidney and strengthen yang.

(4). External treatment of vulvar eczema

There are also four substances in Cnidium extract: osthole, bergamot lactone, isoxaxifragen and xanthoxylin. The first three have a strong inhibitory effect on trichophyton, and the latter has an obvious anti-fungal effect. Therefore, Cnidium Fructus has been regarded as the core medicine for treating skin diseases and pruritus since ancient times.

4.2 Application

(1) Drugs.

(2) Health products.

(3) Food: functional beverage additives.

1. Water decoction method: Precisely weigh 1g of Fructus Cnidii medicinal material powder, put it in a 50ml conical flask with a stopper, add 20mL of distilled water, heat and extract for 1 hour, filter to obtain the filtrate, evaporate the filtrate to dryness, and soak Paste and extract are completely dissolved in methanol and then filtered, and the filtrate is transferred to a 100mL volumetric flask to set the volume to the mark, and filtered through a 0.45μm microporous membrane to obtain the test solution.
2. Ethanol ultrasonic extraction method: Accurately weigh 1g of Cnidium chinensis medicinal material powder, put it in a 50ml conical flask with a stopper, add 20mL of 95% ethanol, ultrasonically extract at room temperature (30±1°C) for 1h, filter , to obtain the filtrate, the filtrate was evaporated to dryness to obtain the extract, the extract was completely dissolved in methanol and then filtered, the filtrate was transferred to a 100mL volumetric flask and fixed to the mark, and filtered through a 0.45 μm microporous membrane to obtain the test solution.
3. Alkaline water immersion extraction method: Accurately weigh 1g of Fructus Cnidii medicinal material powder, place it in a 50ml conical flask with a stopper, add 20ml of 1% NaOH solution, soak at room temperature (30±1°C) for 6h, and use 1096Hcl After acidification, centrifuge to collect the precipitate. The precipitate was completely dissolved with methanol and then filtered, and the filtrate was transferred to a 100mL volumetric flask to set the volume to the mark, and filtered through a 0.45μm microporous membrane to obtain the test solution.
4. Alkali-soluble acid precipitation ultrasonic extraction method: Precisely weigh 1 g of Cnidium chinensis medicinal material powder, put it in a 50 ml conical flask with a stopper, add 20 ml of 1% NaOH solution, soak at room temperature for 1 hour, and ultrasonically extract for 10 minutes. Acidify with 10% HCI and centrifuge to collect the precipitate. Take its precipitation. The precipitate was completely dissolved in methanol and filtered, and the filtrate was transferred to a 100mL volumetric flask to make up to the mark, and filtered through a 0.45μm l microporous membrane to obtain the test solution.

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