Name: China Greater Celandine Extract Manufacturers Suppliers Factory - Wholesale Service - KINTAI
Brand: KINTAIBIO
SKU: 191926572

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of greater celandine extract in China. Please feel free to wholesale high quality greater celandine extract for sale here from our factory. For price consultation, contact us.

1. Product Description

Greater celandine extract is the whole herb extract of Chelidonium majus L., a plant of the Papyraceae family. It has pharmacological activities such as analgesic, cough relieving, anti-inflammatory, anticancer, antibacterial, and choleretic.

Celandine extract has antimicrobial activity, and chelerythrine and sanguinarine can inhibit Gram-positive bacteria. The mixture of chelerythrine and sanguinarine has antifungal activity, and has antibacterial activity against Microsporum canis, Epidermophyton flocculus and Aspergillus fumigatus. Celandine inhibits influenza virus both in vivo and in vitro.

Celandine Extract Suppliers

Kintai is committed to producing and providing you with the best Celandine Extract. The content of Celandine Extract we produce is 2% Chelldonine , 4:1, 10:1. If you have other content requirements, please feel free to contact us.

greater-celandine-extract

Product Quality Standard of Celandine Extract：

Product name	Celandine Extract
Extract source	The whole grass of celandine
Extraction Solvent	Water/Ethyl alcohol
Appearance	Brown yellow powder
Solubility	Easily soluble in water
Identification	TLC , HPLC
Sulphated Ash	NMT 0.5%
Heavy metals	NMT 20 PPM
Loss On Drying	NMT 5.0%
Powder size	80Mesh, NLT90%
Assay of Celandine Extract (HPLC test, percent, Standard in House)	Min. 98.0%
Microbiological Quality (Total viable aerobic count)
- Bacteria, CFU/g, not more than	NMT 10³
- Moulds and yeasts, CFU/g, not more than	NMT 10²
- E.coli, Salmonella, S. aureus, CFU/g	Absence
Storage	Powder: 3 years at - 20 ℃ 2 years at 4 ℃ In Solvent: 6 months at - 80 ℃ 1 month at 20 ℃
Shelf life	Powder storage at room temperature 24 months

2.Extraction process of Celandine Extract

Extraction process

3.Detailed introduction

3.1 Extract source

The white dwarf (Chelidonium majus), the common bivalve plant, the Poaceae, and the white plant. It is the grass of the grass. Perennial herbs. Stem upright, high 30 to 100 RI rice, maybe branch, white powder, Shiso white dwarf juices, and yellow milk. Root root, squid, soil yellow or dark brown, dense root root.
The name of the name: Jiang CHO, the cow golden flower, the peacock, the eight peas, the cutting grass, the Shanxi urushi, the male yellow grass, the mountain yellow, and the Kuro do, the small blood grass, the yellow pepper, the Hu Huang, and the Xiang Fang.
Benefits of total herbal pain, cough, diuretic, detoxification, etc. Lord Haruka: pain Stop cough; Diuretic; Detoxification. Main stomach pain; Abdominal pain; Flame Relief Chronic bronchitis Pertussis; Cough; Jaundice; Water Ascites; Scabbard Caterpillar bite.

Extraction source of Greater celandine extract Celandine

3.2 Active components

Contains chelidonine, chelerythrine, sanguinarine, oxidized chelidonine, pro-opiate, β-allocryptine, DL-tetrahydrocortisone, berberine, chelidonic acid, apple acid, citric acid, succinic acid. It also contains saponins, cardiac glycosides, flavonols, and chelidonol.

4.Benefits and Application

The main active ingredients of Celandine Extract, which have many unique effects as below:

1). Sedative and analgesic effects
Chelidonine has an analgesic effect similar to that of morphine, can significantly increase the pain threshold, and the analgesic effect can last for 4 to 48 hours. It has a paralyzing effect on the sensory nerve endings, and the response wave of electrical stimulation can be seen to be prolonged in isolated neuromuscular specimens. Celandine extract has weak sedative and hypnotic effects on the central nervous system.

Sedative and analgesic effects of Greater celandine extract

2). Anticancer effect
Celandine has the activity of inhibiting cancer and delaying the growth of malignant tumors. Celandine has a killing effect on esophageal cancer cells.

3). Antispasmodic and cough-relieving effects
Celandine can prevent the occurrence of anaphylactic shock or histamine shock, and has antitussive effect. The antitussive effect of chelidonine can directly act on the cough center of the central nervous system, and has anti-parasympathetic and anti-histamine activities.

Antitussive effect of Greater celandine extract

4). Anti-inflammatory effect Of Greater celandine extract

Anti-inflammatory effect of Greater celandine extract

5). Antibacterial and antiviral effects
Chelidonine and sanguinarine can inhibit Gram-positive bacteria and Candida albicans. Celandine inhibits influenza virus both in vivo and in vitro. It has inhibitory effect on catarrhal coccus, staphylococcus albus, streptococcus A, staphylococcus aureus, Escherichia coli, tubercle bacillus, pertussis bacillus, etc., and also has inhibitory effect on some fungi.

6). Effect on smooth muscle
Celandine injection has a relaxing effect on smooth muscle, and at the same time has a significant effect on relieving smooth muscle spasm, and has obvious antagonism on smooth muscle spasm caused by antigens, histamine, cholinergic drugs (such as pilocarpine) and barium chloride .

7). The effect on the cardiovascular system
Chelidonine can excite the heart, increase blood pressure, and dilate coronary arteries. Can slightly and permanently reduce arterial pressure without affecting breathing. β-homochelidonine can cause a transient drop in blood pressure in animals, slow down the heart rate, and paralyze the vasomotor center in large doses.

8). Anti-hepatotoxic activity
Celandine ethanol extract can provide effective protection against the increase of plasma ALAT, ASAT and LDH caused by carbon tetrachloride; ALAT is a marker enzyme. Less protection against carbon tetrachloride-induced alkaline phosphatase activity.

Antihepatotoxic effect of Greater celandine extract

9). Choleretic effect
Celandine total extract, phenolic components and alkaloids can promote bile secretion, increase bile flow, reduce bile acid content, and have obvious choleretic effect. Total celandine extract produces choleretic effects by increasing bile acid-independent bile flow.

Application

Celandine Extract is widely used in the field of medicine or health products. It is used to relieve pain, cough, diuresis and detoxification. For gastrointestinal pain, jaundice, edema, scabies, sores, snakebites; Chronic tracheitis.

5.Physical and chemical identification

Take 5g of sample powder, wet it with ammonia water and mix well, add 50ml of chloroform, soak overnight, filter, concentrate the chloroform solution to 2ml, and use it as the test solution (I); remove the residue after chloroform filtration, fully evaporate the solvent, soak in methanol Overnight, then filtered, the methanol solution was concentrated to 2ml, and used as the test solution (II). Spot the test solution on the silica gel G-0.5%NaOH plate, the chloroform leaching part (I) uses hexane-chloroform-methanol (6:3:0.3) as the developing solvent, and uses chelidonine, tetrahydro-cortisone, Chelidonine and sanguinarine were used as controls. The methanol leached part (Ⅱ) was developed with chloroform-methanol (9:1), and berberine and coptisine were used as controls. With a span of 10cm, inspect under an ultraviolet lamp (254-365nm), and then spray to improve the color development of the potassium bismuth iodide test solution.