Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of urolithin a powder in China. Please feel free to wholesale high quality urolithin a powder for sale here from our factory. For price consultation, contact us.
bulk Urolithin A powder supplier-Kintaibio®
As a global leader in Urolithin A production, Kintaibio® is dedicated to providing high-purity, high-quality Urolithin A powder to support innovation in anti-aging and health sectors.
Urolithin A is a natural metabolite known for its unique ability to activate mitochondrial autophagy. It helps enhance cellular energy metabolism, slows the decline of age-related functions, and supports muscle and cognitive health. Kintaibio® produces high-purity Urolithin A powder through a microbial fermentation process, ensuring scalability and consistency for research, pharmaceutical, and nutraceutical applications. Our products are manufactured under strict cGMP and ISO standards, ensuring a purity of ≥98%, free from solvent residues, and safe for use.
Kintaibio® offers flexible supply options ranging from grams to tons, along with customized technical services to optimize product stability and bioavailability. We provide comprehensive third-party testing reports (COA, MSDS, etc.), with full traceability, helping you efficiently and compliantly develop innovative solutions.
Specifications
- Purity: ≥98% (HPLC analysis, USP-compliant)
- Appearance: Light yellow crystalline powder
- Urolithin a solubility: Slightly soluble in water (<0.1 mg/mL), readily soluble in DMSO and ethanol
- Stability: 36 months under 25°C in sealed, light-protected containers
- Residual Solvents: Undetectable (GC-MS detection limit <10 ppm)
- Microbial Limits: Complies with EP 2.6.12/2.6.13 (Total aerobic microbial count <100 CFU/g; molds/yeasts <10 CFU/g)
COA of Urolithin A Powder
Production & Quality Control of Kintaibio® Urolithin A Powder
Manufacturing Process:
Quality Assurance:
Compliant with cGMP (21 CFR Part 111) and ISO 9001:2015 standards
Batch-specific testing includes HPLC (purity), GC-MS (solvents), ICP-MS (heavy metals), and full microbial analysis
Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and stability study reports
urolithin a health benefits
urolithin a for skin
Recent studies have found that Urolithin A (UroA) can mitigate UVA-induced photoaging-related damage in *in vitro* models using human dermal fibroblasts. Research indicates that UroA reduces the intracellular accumulation of reactive oxygen species (ROS) following UVA exposure and promotes NRF2 phosphorylation and its translocation to the nucleus; this activates NRF2/ARE-mediated antioxidant defense mechanisms, thereby helping cells cope with oxidative stress. Concurrently, UroA promotes mitophagy, improving mitochondrial function and cellular homeostasis compromised by UVA exposure.
In these experiments, pure urolithin a also alleviated UVA-induced effects such as inhibited fibroblast proliferation, increased senescence-associated β-galactosidase activity, extracellular matrix degradation, SASP-related changes, and cell cycle arrest. Consequently, current cellular studies suggest that Urolithin A powder holds potential value for combating oxidative stress, maintaining mitochondrial function, and ameliorating UVA-induced cellular photoaging phenotypes.
urolithin a weight loss
In recent years, the potential role of urolithin A (UA) in weight management has garnered research interest. Studies using mouse models of high-fat diet-induced obesity have shown that UA increases energy expenditure by promoting thermogenesis in brown adipose tissue (BAT) and inducing the "browning" of white adipose tissue (WAT), thereby reducing the weight gain and fat accumulation caused by a high-fat diet.
Further mechanistic studies indicate that UA elevates levels of active thyroid hormone (T3) within adipose tissue. Notably, when thyroid hormone synthesis is inhibited, the effects of UA on adipose tissue thermogenesis, WAT browning, and weight control are significantly attenuated, suggesting that thyroid hormone-related pathways may be involved in the process by which UA regulates energy expenditure. Consequently, current research indicates that urolithin A powder promotes adipose tissue thermogenesis, increases energy expenditure, and supports healthy weight management.
urolithin a and kidney disease
Existing research indicates that Urolithin A (UroA) possesses potential properties such as antioxidant and anti-inflammatory effects, as well as the ability to regulate cellular homeostasis. In the context of renal health, a study found that UroA can alleviate renal tissue damage and reduce macrophage infiltration and the expression of pro-inflammatory cytokines, thereby demonstrating potential for counteracting renal fibrosis; mechanistic studies further suggest that UA may mitigate responses associated with renal fibrosis by inhibiting the TGF-β1/Smad and MAPK signaling pathways.
Based on current evidence, Urolithin A powder shows promise in areas involving the regulation of oxidative stress, control of inflammatory responses, maintenance of renal tubular cell homeostasis, and mechanisms underlying renal fibrosis, making it a research-worthy ingredient in the fields of renal and metabolic health.
urolithin a inflammation
The application of Urolithin A (UroA) in the regulation of inflammatory responses has also garnered significant attention. Research has demonstrated that in both lipopolysaccharide (LPS)-induced BV2 microglial cell models and MPTP-induced mouse models of Parkinson's disease, UroA promotes microglial mitophagy, facilitating the clearance of damaged mitochondria and improving mitochondrial function, while simultaneously attenuating excessive pro-inflammatory responses.
Further mechanistic studies indicate that UroA powder inhibits the activation of the NLRP3 inflammasome, thereby reducing downstream inflammation-related reactions. Notably, the neuroprotective effects of UroA are partially attenuated when microglial mitophagy is blocked-either pharmacologically or genetically-suggesting that its anti-inflammatory action is closely linked to the mechanism of "promoting mitophagy-improving mitochondrial quality-inhibiting NLRP3 inflammasome activation."
urolithin a muscle growth
Urolithin A also plays a role in maintaining muscle function and muscle mass. Existing research suggests that UroA may support normal muscle function by promoting mitophagy and enhancing mitochondrial quality control-processes that help skeletal muscle cells clear damaged mitochondria and maintain energy metabolism and cellular homeostasis.
Meanwhile, some preclinical studies indicate that pure urolithin a powder may influence metabolic pathways associated with muscle protein synthesis, growth, and atrophy; furthermore, through its antioxidant and anti-inflammatory effects, it helps create a cellular environment conducive to maintaining healthy muscle tissue.
- Urolithin A and Gut Bacteria: Urolithin A is a bioactive metabolite produced through the metabolic activity of specific gut microorganisms. Research indicates that gut microbiota composition varies among individuals, leading to differences in the body's ability to produce Urolithin A; supplementing with Urolithin A powder can mitigate the impact of these individual metabolic differences on UroA formation.
- Urolithin A and Brain Health: UroA promotes mitophagy-the process by which cells clear away damaged mitochondria-prompting researchers to investigate its potential role in mitochondrial quality control within neurons and overall brain health. Studies have linked UroA to various mechanisms associated with neuroinflammation, oxidative stress, and neurodegenerative changes.
- Urolithin A and Blood Pressure: UroA influences cellular function through pathways related to mitochondrial quality control, oxidative stress, and inflammation, making it a subject of interest for cardiovascular health research. However, current systematic reviews of human studies have not found sufficient evidence to conclude that UroA consistently improves blood pressure or other major cardiovascular outcomes.
- Urolithin A and Cholesterol: This is another area of metabolic health currently under investigation. Research has explored UroA's mechanisms regarding fatty acid oxidation, lipid metabolism, and mitochondrial function, with some preclinical studies observing potential changes related to lipid metabolism. However, current human studies are insufficient to confirm that UroA directly lowers total cholesterol or LDL-C, or improves dyslipidemia.
- Urolithin A and Diabetes: Research in this area focuses primarily on glucose metabolism, insulin sensitivity, and adipose tissue metabolism. Animal studies suggest that UroA may influence glucose homeostasis by promoting energy expenditure, enhancing fatty acid oxidation, and modulating metabolic inflammation.
- Urolithin A and Hair Growth: Given that hair follicle cell growth, energy supply, and aging are closely linked to mitochondrial function-and considering UroA's role in promoting mitophagy and maintaining mitochondrial quality-the potential connection between UroA and hair follicle health warrants further study.
- Urolithin A and Liver Health: As the liver is a vital metabolic organ where mitochondrial function and lipid metabolism play key roles, UroA's ability to support mitochondrial quality control makes it a promising candidate for research into metabolic health.
Reference:https://www.sciencedirect.com/science/article/abs/pii/S1011134422000768
https://pmc.ncbi.nlm.nih.gov/articles/PMC7141696/
https://www.sciencedirect.com/science/article/pii/S1756464621001961
https://www.sciencedirect.com/science/article/abs/pii/S0028390822000223
https://www.sciencedirect.com/science/article/pii/S2666379122001586
urolithin a uses
Urolithin A Supplements
Urolithin A serves as an active ingredient for Urolithin A supplements, enabling the development of various dosage forms-such as urolithin a capsules, tablets, pills, and gummies-with formulations tailored to target market regulations and specific product positioning.
Urolithin A Cosmetics
Given its potential in areas such as mitochondrial health, oxidative stress, and cellular aging, Urolithin A is also suitable for developing anti-aging and skin health products (e.g., urolithin a cream and facial lotions). Product development can be further optimized by leveraging data on formulation stability, skin penetration, and efficacy.
Urolithin A Pharmaceutical Research
As Urolithin A is closely linked to research areas such as mitophagy, muscle health, oxidative stress, and the regulation of inflammation, it currently serves as a candidate molecule in pharmaceutical and life science research targeting age-related diseases, declining muscle function, and neurodegenerative disorders.
For various types of Urolithin A products, Kintaibio® supplies stable Urolithin A powder and offers customized support regarding specifications, purity, testing parameters, and application development, providing comprehensive ingredient solutions for dietary supplements, functional foods, cosmetics, and life science research.
Urolithin A Powder side effects,dosage,safety
How much Urolithin A should I take?
There is currently no standardized therapeutic dosage applicable to all adults. Therefore, the specific daily intake should be determined based on factors such as product formulation, raw material specifications, target demographics, intended use, and local regulatory requirements. It is not recommended to derive human dosages solely from doses used in animal studies.
Is Urolithin A safe?
Existing human clinical studies generally demonstrate good short-term tolerability. Furthermore, preclinical toxicology studies have revealed no significant genotoxicity or major target-organ toxicity associated with Urolithin A at the tested dosages.
- Urolithin A side effects: In human trials conducted to date, reported adverse events have generally been mild to moderate in severity. Additionally, some randomized controlled studies showed no significant difference in the incidence of adverse events between the Urolithin A group and the placebo group.
- Urolithin A drug interactions: There is currently insufficient human clinical evidence to establish a comprehensive and definitive list of drug interactions. Therefore, individuals taking prescription medications, those with chronic medical conditions, or those using multiple medications simultaneously should consult a physician or pharmacist before supplementing with Urolithin A.
- Urolithin A contraindications: There is currently no standardized list of contraindications established through large-scale human clinical trials. Consequently, one should not arbitrarily expand or fabricate a list of contraindications; instead, a professional assessment based on individual health status and local regulations is advised.
- Urolithin A and pregnancy: There is currently insufficient clinical data regarding pregnant women; therefore, the safety of long-term use during pregnancy or lactation has not been established. As a precaution, pregnant and breastfeeding women are advised against supplementing with Urolithin A without professional medical guidance.
- Urolithin A FDA: Regarding FDA GRAS Notice No. 791, the agency issued a "no questions" conclusion concerning a specific Urolithin A ingredient and its intended food uses, meaning the FDA raised no objections to the safety conclusions presented in the notice.
where can i buy urolithin a ?
If you are seeking a reliable supplier of Urolithin A or its raw materials, KINTAIBIO® offers Urolithin A powder suitable for product development in areas such as dietary supplements, nutraceuticals, sports nutrition, and functional skincare. As a china urolithin a powder supplier, we prioritize raw material quality, production process control, and batch-to-batch consistency; we can provide specifications, Certificates of Analysis (COA), testing data, and technical documentation tailored to your requirements.
For customers looking to purchase Urolithin A, we offer competitive urolithin a pricing based on order volume, product specifications, and target market needs. Whether you require small quantities for R&D or are seeking a source for long-term commercial procurement, we can provide specification confirmation, sample support, and bulk supply solutions. Please contact sales@kintaibio.com for more information.
FAQ
Q: Does Urolithin A really work?
A: Urolithin A is a metabolite of ellagitannins and ellagic acid produced through the action of gut microbiota. The mechanism currently attracting the most research interest is its ability to promote mitophagy-a process that helps the body clear dysfunctional mitochondria and maintain mitochondrial quality. Clinical studies have observed that Urolithin A supplementation is associated with improvements in certain aspects of muscle endurance and strength, as well as mitochondrial-related biomarkers.
Q: What does Urolithin A do?
A: A key area of research regarding Urolithin A focuses on mitochondrial quality control. When some mitochondria within a cell experience a decline in function, mitophagy helps identify and clear the damaged mitochondria, thereby maintaining cellular energy metabolism and mitochondrial homeostasis.
Q: How does Urolithin A work?
A: The most notable mechanism of action for Urolithin A is the promotion of mitophagy and mitochondrial quality control. Simply put, mitochondria are vital energy-producing centers within cells; however, factors such as aging, oxidative stress, or increased metabolic burden can lead to a decline in mitochondrial function. Research suggests that Urolithin A supports healthier mitochondrial renewal by modulating signaling pathways related to mitophagy, cellular metabolism, and inflammation, thereby facilitating the cellular processing of damaged mitochondria.
Q: Can Urolithin A cause insomnia?
A: There is currently insufficient clinical evidence in humans to prove that Urolithin A directly causes insomnia. Published human studies have primarily focused on muscle function, mitochondrial health, inflammatory markers, and safety, without establishing a clear causal link between Urolithin A and insomnia.
Q: Who should take Urolithin A?
A: Current research on Urolithin A primarily involves healthy adults, middle-aged and older individuals, and those interested in athletic performance, muscle health, and healthy aging. However, findings from studies on healthy adults should not be simply extrapolated to pregnant or breastfeeding women, children, individuals undergoing medical treatment, or those with chronic diseases. Such individuals should consult a doctor or pharmacist before deciding whether to use it.
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