tannic acid powder

As a specialized Chinese manufacturer dedicated to the R&D and production of tannic acid powder,KINTAIBIO utilizes Chinese gallnuts as our primary source material. Classified as a high-molecular-weight hydrolyzable polyphenolic compound, tannic acid possesses the chemical formula C₇₆H₅₂O₄₆. It presents as a pale yellow to light brown, amorphous, and loose powder. It is readily soluble in water, ethanol, and acetone, yet insoluble in diethyl ether, benzene, and chloroform; furthermore, it gradually darkens upon exposure to air and exhibits a certain degree of hygroscopicity. Our tannic acid product line offers various purity specifications-including 50%, 80%, 96%, and 98%-to precisely meet the diverse requirements for active ingredient content across different industries.

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The tannic acid-a secondary metabolite abundantly present in Chinese gallnuts-is extracted and refined through highly efficient esterification reactions and rigorous separation-purification processes. This methodology ensures the complete preservation of the polyphenolic hydroxyl structures and ester bond characteristics inherent to the molecule. Every production batch undergoes rigorous chemical identification testing: when an aqueous solution of the product is mixed with iron salts, it immediately turns a characteristic blue-black color, thereby verifying its identity as a hydrolyzable tannin. Moreover, our facility is equipped with an advanced analytical laboratory capable of quantitatively characterizing the antioxidant capacity, free radical scavenging rate, and protein precipitation performance of each batch, thereby guaranteeing the authenticity and reliability of our products.

Thanks to its remarkable antioxidant, antimicrobial, and protein-precipitating properties, our bulk tannic acid powder plays a pivotal role across the pharmaceutical, food, daily chemical, and agricultural sectors. In the pharmaceutical realm, its antiviral, antimutagenic, and free radical-scavenging activities are harnessed in the development of medicinal formulations and health supplements. Within the food industry, it serves as a natural astringent and antioxidant, contributing to the extension of product shelf life. In the field of daily chemicals, its characteristic color-forming reaction with iron salts-historically making it a core ingredient in the manufacture of blue ink-has evolved to find modern applications in leather tanning, cosmetics, and various functional daily-use products.Welcome to contact us at sales@kintaibio.com for information regarding tannic acid powder.

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Raw Material Pre-treatment and Crushing

The procured high-quality gallnuts undergo mechanical crushing to remove impurities and non-tannin components, yielding gallnut fragments of uniform particle size.

Hot Water Extraction

The crushed gallnuts are loaded into an extraction tank, where hot water-maintained at a temperature of 30–50°C-is added. The mixture is then extracted under gentle agitation for 1 to 3 hours. In actual production, to balance both efficiency and yield, the extraction duration is typically controlled within a range of 1.5 to 2.5 hours. The hot water temperature is stabilized via jacket heating; this specific temperature range effectively prevents the degradation of tannic acid through hydrolysis or oxidation caused by excessive heat. Upon completion of the extraction process, a tannic acid extract solution is obtained.

Ultrafiltration Concentration and Purification

The extract solution is fed into an ultrafiltration system utilizing membranes with a molecular weight cut-off (MWCO) of 2,000–3,000 Daltons. The operating temperature is strictly controlled between 38°C and 42°C, while the operating pressure is maintained within the range of 9 to 12 bar. During the filtration process, pure water-added in a volume equivalent to 0.3 to 1 times that of the original extract solution-is introduced into the circulation tank to facilitate continuous filtration. The process ultimately yields a high-purity tannic acid concentrate and an ultrafiltration permeate.

Spray Drying

The tannic acid concentrate is fed directly into a spray drying tower. A high-speed centrifugal atomizer disperses the liquid feed into fine droplets, allowing the water content to evaporate rapidly within a stream of hot air, thereby producing a loose, amorphous powder ranging in color from yellow to light brown. The inlet and outlet air temperatures of the drying tower are optimized based on the thermal stability of the product to ensure that the final tannic acid content consistently meets target specifications.

Permeate Recovery and Utilization

The permeate generated during the ultrafiltration step contains small quantities of low-molecular-weight organic compounds alongside a large volume of water. This permeate is channeled into a reverse osmosis system for concentration; the recovered pure water is then recycled directly back into the hot water extraction process for the gallnuts. As for the reverse osmosis concentrate (retentate), a decision is made regarding whether to incorporate it into the main extract solution or subject it to separate processing, based on its specific tannic acid content.

How Does Tannic Acid Stop Bleeding?

By virtue of its unique polyphenol hydroxyl structure and reactivity toward Michael addition, tannic acid serves as an ideal functional component for constructing high-performance hemostatic materials. Studies have demonstrated that composite microspheres prepared by crosslinking gelatin with tannic acid (TGMs)-once functionalized via the electrostatic adsorption of quaternized chitosan (CQAS) or calcium ions (Ca²⁺)-exhibit rapid water absorption within 3 seconds. Notably, the water absorption capacity of the resulting T₂GMs-CQAS is 2.95 times that of ordinary gelatin microspheres.

 

Benefiting from the rapid water absorption, coagulation pathway activation, and erythrocyte aggregation effects conferred by the tannic acid crosslinked network, both materials achieve rapid blood coagulation in vitro; simultaneously, their positively charged surfaces endow them with potent antibacterial activity. These advancements clearly demonstrate that tannic acid powder-crosslinked gelatin microspheres hold broad promise for applications in the management of irregular bleeding wounds that cannot be treated with pressure bandaging.

Tannic Acid Powder Antibacterial

Studies indicate that by anchoring tannic acid-coordinated with Ca²⁺ ions-onto the surface of chitin nanofiber sponges via layer-by-layer deposition, the resulting TA/Ca(II) coating significantly enhances the sponges' antibacterial properties; furthermore, this antibacterial efficacy intensifies as the tannic acid content increases. This coordination-based composite coating not only preserves the rapid hemostatic capability inherent in the sponge's mesoporous-macroporous structure but also endows the material with potent, broad-spectrum antibacterial activity.

 

Its mechanism of action is closely linked to the polyphenolic hydroxyl groups of tannic acid: these groups chelate the metal ions essential for microbial growth, inhibit key enzymatic activities, and disrupt the permeability of pathogenic bacterial cell membranes, thereby achieving highly efficient bacterial inhibition. The aforementioned research conclusively demonstrates that tannic acid powder serves as a core functional component for constructing advanced wound dressings that combine both rapid hemostasis and durable antibacterial efficacy.

Tannic Acid Powder antioxidant

Relevant studies indicate that, in cell-free systems, tannic acid powder demonstrates superior efficiency compared to gallic acid in scavenging DPPH• radicals, superoxide anions, peroxyl radicals, nitric oxide, and peroxynitrite; furthermore, it exhibits superior performance in inhibiting elastase and presents a broader ultraviolet absorption spectrum.

 

In an L929 fibroblast model exposed to UVB irradiation, tannic acid significantly mitigates redox imbalance by inhibiting the generation of reactive oxygen species, the activation of NADPH oxidase, and the depletion of the endogenous antioxidant defense system. Moreover, by suppressing lipid peroxidation, mitochondrial transmembrane potential depolarization, DNA damage, and the expression of MMP-1, it effectively prevents cellular photodamage and the ensuing photoaging phenomena. These findings demonstrate that tannic acid possesses potent antioxidant, anti-collagenase, and anti-elastase activities, thereby exhibiting immense potential for application in the field of anti-photoaging.

Tannic Acid Powder for skin

To address pressure- and friction-induced skin injuries resulting from the prolonged use of Personal Protective Equipment (PPE), an in vivo study utilizing a specialized skin analysis system yielded significant findings: the application of a specific hydrogel patch beneath a face mask resulted in a statistically significant increase in skin hydration levels, accompanied by a marked reduction in facial erythema. Concurrently, no abnormal fluctuations were observed in facial skin temperature, sebum secretion, or transepidermal water loss; this indicates that the patch effectively enhances skin hydration without disrupting normal physiological metabolic processes.

 

Consumer sensory evaluations also provided positive feedback. These results conclusively demonstrate that tannic acid powder-leveraging the astringent, soothing, and anti-inflammatory properties conferred by its polyphenol structure-plays a pivotal role in the prevention and management of PPE-related skin complications.

Reference:https://www.sciencedirect.com/science/article/abs/pii/S2352492824011863

https://www.sciencedirect.com/science/article/abs/pii/S0141813020332451

https://www.sciencedirect.com/science/article/abs/pii/S0891584920312144

https://www.sciencedirect.com/science/article/pii/S0378517323011535

In practical applications, tannic acid demonstrates diverse utility, leveraging its potent antioxidant, astringent, and antimicrobial properties.

Tannic Acid Powder Medical Uses

Tannic acid is primarily utilized for topical application-for instance, as an ingredient in tannic acid creams or hydrogels-to alleviate symptoms associated with cold sores, diaper rash, and sore throats, as well as to staunch minor bleeding. Early studies also suggest that, when combined with gelatin as a specialized medical food, tannic acid can aid in managing acute diarrhea in children.

Tannic Acid Powder Supplements

It is important to note that, due to potential toxicity risks, tannic acid is not considered a standard dietary supplement. The use of oral formulations-such as tannic acid tablets or capsules-is strictly restricted and requires administration under professional medical guidance.

Tannic Acid Powder Hydrolysis

In the industrial sector, both tannic acid itself and the products derived from its hydrolysis are widely employed in the pretreatment of wood prior to staining, for rust prevention on iron products, and in the manufacturing of leather and blue ink.

Is Tannic Acid Poisonous?

Regarding safety, a scientific opinion published by the European Food Safety Authority (EFSA) in 2014 explicitly stated that tannic acid is safe for use as a feed flavoring agent across all animal species, provided that its concentration does not exceed the limit of 15 mg per kilogram of feed (15 mg/kg feed). The only caveat is that during handling, precautions must be taken to avoid exposure-whether through skin contact, eye contact, or inhalation-which could pose a hazard to workers.

The U.S. Food and Drug Administration (FDA) has also recognized tannic acid as a substance that is "Generally Recognized as Safe" (GRAS). It is approved for use as a direct food additive, serving as a flavoring agent, stabilizer, or processing aid. For instance, the maximum allowable concentration is 0.01% in baked goods, 0.015% in alcoholic beverages, and 10 ppm (0.001%) in meat products and similar items

Side Effects of Tannic Acid Powder

Regarding side effects and dosage, professional medical information platforms indicate that oral ingestion of tannic acid is safe when consumed at the typical levels found in food. However, ingesting large doses orally may cause gastric irritation, nausea, and vomiting; extremely large doses could even result in liver damage. Furthermore, the long-term consumption of high concentrations of tannic acid is believed to be potentially linked to an increased risk of nasopharyngeal carcinoma.

When applied topically-for example, as a tannic acid cream-over large areas of the skin or to broken skin for prolonged periods, systemic absorption may occur, thereby posing a risk of toxicity. Consequently, tannic acid products must be used strictly within recommended dosages and for approved indications; their application to large areas of damaged skin, as well as their use by specific populations such as children or pregnant women, must be strictly avoided.

As a professional producer and direct manufacturer of hydrolyzed tannic acid powder, we provide a stable supply-ranging from samples to ton-scale quantities-to clients worldwide. You can purchase tannic acid directly through our official channels, bypassing multiple layers of intermediaries. Our product range features various purity specifications-including 50%, 80%, 96%, and 98%-and is available in bulk quantities to meet the large-scale procurement needs of industries such as animal feed, pharmaceuticals, and daily chemicals.

Whether you are looking to buy tannic acid powder or simply wish to inquire about pricing, our sales team is ready to respond promptly. As a trusted supplier, we guarantee that every batch of tannic acid powder possesses high purity, low impurity levels, and stable biological activity. If you are searching for a local supplier or high-quality tannic acid powder, we invite you to contact us directly to request samples and a Certificate of Analysis (COA). Our standard tannic acid products can be customized regarding particle size and moisture content to meet your specific requirements. By choosing us, you opt for a direct-from-factory purchasing experience, making the acquisition of tannic acid powder bulk simpler, more efficient, and more professional.

★If you want to get high-quality tannic acid powder, please feel free to contact us at sales@kintaibio.com or feedback on the next page.