Macleaya Cordata Extract

Macleaya Cordata Extract (MCE) produced by Kintaibio^® is made from the fruit pods of the poppy family plant Macleaya cordata. It is extracted by acidic aqueous solution combined with pH-controlled alkaline precipitation to achieve directional and efficient concentration of active ingredients. Our production process follows GMP, ISO, and HACCP quality management systems. The current standard content of total alkaloids produced is 60% (sanguinarine>40%, chelerythrine>15%). We can also customize the production of the main active ingredient Sanguinarine according to your formula. The existing process has achieved large-scale commercial production, and each batch of our products has passed strict testing to ensure that the efficacy of our products meets your intended use.

Total Alkaloids 60% (Sanguinarine>40%,chelerythrine>15%)

Macleaya cordata Extract

Product name: Macleaya Cordata Extract
Source of raw materials: Fruit pods of Macleaya cordata, a plant of the Poppy family
Core ingredients: The main active ingredients are benzophenanthridine alkaloids, including sanguinarine and chelerythrine.
Total alkaloid content of this product: ≥ 60% (based on dry matter, confirmed by HPLC test).
The Following Specifications Can Be Customized Based On Your Specific Needs.

To ensure you receive comprehensive after-sales support, our dedicated R&D team is available to handle your inquiries and provide all necessary technical information regarding the MCE. Please feel free to contact us at Sales@Kintaibio.Com for any assistance you may require.

3.1 Raw material advantages:

Kintaibio^® Macleaya cordata extract (MCE) uses the mature fruit pods of high-quality Macleaya cordata plants from Northeast China as raw materials. The region's unique cold temperate climate and fertile soil environment are conducive to the natural enrichment of core alkaloids (such as sanguinarine and chelerythrine) in the fruit, providing a highly active material basis for the extract.

We implement strict source control through exclusive cooperative planting bases, including the selection of seed sources, standardized planting (following the requirements of no pesticide residues) and precise harvesting of mature fruit pods. The raw materials must undergo multiple tests (alkaloid content, pesticide residues, heavy metals, etc.) before entering the factory to ensure compliance with pharmacopoeias and international standards, and have complete batch traceability information, which guarantees the purity of the raw materials, the content of active ingredients and the stability and reliability of supply.

 

3.2 Production process flow chart

Crush pods → Remove impurities → Dry → Acidic extraction → Filter → Make alkaline → Filter → Dissolve in ethanol → Filter → Concentrate → Dry → Crush extract.

Our Macleaya Cordata Extract testing projects include, but are not limited to:

• Total alkaloid content (HPLC method) Testing the main active ingredients of benzophenanthridine alkaloids
• Sanguinarine and chelerythrine content (HPLC method)
• Water
• Heavy metals (lead, arsenic, cadmium, mercury)
• Microbial indicators (Salmonella, total mold, etc.)

We will provide you with a complete quality inspection report (COA) for each batch. The following is pre-COA.

2025 testing technology update:

We mainly use UPLC-ESI-MS coupling technology (ultra-high performance liquid chromatography-mass spectrometry) for component analysis. Its sensitivity: 0.01 μg/mL is 3 times that of conventional HPLC. The consumption of solvents is 60% lower than that of HPLC.
Quality control: To ensure batch consistency, we have tested the active ingredient content of production data for 12 consecutive months, and the fluctuation range is ≤ ±5%.

For more detailed HPLC and UPLC-ESI-MS detection method documents, please contact sales@kintaibio.com to obtain them.

final product packing details 

Macleaya Cordata Extract inner packing details

outer packing details of Macleaya Cordata Extract

Based on scientific research and experimental data, the observed biological activities of Macleaya Cordata Extract are:
 

Antimicrobial effect: In vitro and in vivo studies have shown that this product has an inhibitory effect on a variety of Gram-positive bacteria (such as Staphylococcus aureus, Streptococcus) and some Gram-negative bacteria (such as Escherichia coli, Salmonella). Its antimicrobial activity is mainly related to the ability of alkaloids to interfere with bacterial cell membrane function and nucleic acid synthesis.

Reference:https://jasbsci.biomedcentral.com/articles/10.1186/s40104-022-00766-4/figures/10

Anti-inflammatory effect: Animal experimental models show that this product may reduce the inflammatory response of the intestine and other tissues by regulating inflammatory signaling pathways (such as NF-κB).

Promoting growth performance: In feeding trials of pigs, poultry and other animals, it was observed that the addition of this product helps to increase average daily weight gain (ADG) and improve feed conversion rate (FCR/feed-to-meat ratio). It has the effect of promoting growth performance, which is believed to be related to its improvement of intestinal health (inhibition of harmful bacteria, reduction of inflammation, maintenance of intestinal barrier) and thus optimizing nutrient absorption efficiency.

a.Feed replacement antibody
The main active ingredients of Macleaya Cordata Extract are sanguinarine and chelerythrine, which have strong anti-inflammatory activity. In animals, by inhibiting the outbreak of inflammation, improving intestinal health, and then improving animal growth performance, that is, "anti-inflammation, intestinal regulation, promoting the perfect feed-replacing mechanism for 'growth'.

b.Protein booster
MCE can inhibit the activity of amino acid decarboxylase and monoamine oxidase, reduce the degradation of amino acids in the intestine, and maintain the integrity of the animal intestine through "anti-inflammation and intestinal adjustment", thereby improving the digestion and absorption efficiency of protein and other nutrients in the feed.

c.Efficient growth
Through anti-inflammatory and intestine-regulating effects, MCE can reduce animal intestinal inflammation, reduce ineffective consumption of nutrients, and promote body anabolism; maintain intestinal integrity, optimize intestinal microbial flora, improve nutrient utilization efficiency, and promote muscle tissue nutrient deposition.

As a feed additive, it is used in pigs, poultry (chickens, ducks, etc.), ruminants and aquaculture.

• It is mainly used to support animal intestinal health and assist in improving growth performance.
• In some countries and regions, it can be used to respond to regulatory requirements to reduce the use of feed antibiotics (AGP) (such as Announcement No. 194 of the Ministry of Agriculture and Rural Affairs of China).
• Macleaya Cordata Extract can also be used as veterinary drug raw materials for oral preparations to prevent and treat respiratory diseases of livestock and poultry (such as swine panting disease and chicken cough and runny nose), shortening the recovery period. And it can be used as a biological pesticide to effectively kill pests such as mites, snails, maggots, aphids, etc.

Recommended use:

• Applicable animals: pigs, poultry, ruminants, aquatic animals, etc.
• Addition stage: It can be based on your product positioning instructions, such as: use throughout the process, or specific stages such as nursery period and fattening period.
• Recommended addition amount: Mixed with daily diet (recommended addition amount 0.1%-0.5%) to improve the weight gain rate of meat poultry and the egg quality of laying poultry. The actual amount you add should be determined based on the animal species, growth stage, feeding goals and regulatory requirements.

The dosage of Macleaya Cordata Extract manufactured by Kintaibio^® added in the feed

Looking for bulk Macleaya Cordata Extract for your feed additive projects?

Kintaibio Feeding manufactures and supplies pure, 100% natural Alkaloid extract and Sanguinarine powder from Macleaya Cordata. 

We specialize in providing high-quality, standardized Sanguinarine products. All product claims are supported by verifiable scientific data and experimental results. We offer necessary product technical documentation (such as COA, MSDS, application guidelines) and technical support.  For more information on product specifications, application solutions, test data, or to request samples, please contact Kintaibio's sales department at sales@kintaibio.com.

Kintaibio^® Sanguinarine Advantages and Product Features:

• Clear ingredients and stable content: The core active ingredients (sanguinarine, chelerythrine) are clear, and the content is standardized to ensure batch-to-batch consistency.
• Technology leadership: Master a variety of advanced extraction technologies, and continuously optimize the process to ensure high product activity and batch stability.
• Natural plant source: Extracted from the natural plant Macleaya, it has become an ideal choice for replacing antibiotic feed additives and green pesticides.
• Regulatory compliance: The product complies with the requirements of China's "Feed Additive Variety Catalog", relevant announcements of the Ministry of Agriculture and Rural Affairs, and EU Feed Additives Regulations.
• Safety: Used at the recommended dose, it has been evaluated by EFSA for safety. Metabolic studies have shown that it has a low risk of residues in animals. The Macleaya total alkaloid extract we produce is completely consistent with the quality standards of Macleaya Extract Pesticide registered by the US EPA.

★If you want to get high-quality Macleaya cordata Extract Powder, please feel free to contact us at sales@kintaibio.com or provide feedback on the next page.

Hot Tags: macleaya cordata extract, China macleaya cordata extract manufacturers, suppliers, factory, Black currant fruit extract, Cassia Tora Extract, Lotus Plumula Nelumbinis Extract, Great Burdock Fruit Extract, Cranberry N.America extract, Emblica officinalis Extract