pure hyaluronic acid powder

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of pure hyaluronic acid powder in China. Please feel free to wholesale high quality pure hyaluronic acid powder for sale here from our factory. For price consultation, contact us.

pure hyaluronic acid powder is a multifunctional matrix, and hyaluronic acid (hyaluronic acid) HA is widely distributed in various parts of the human body. The skin also contains a lot of hyaluronic acid. The maturation and aging process of human skin also changes with the content and metabolism of hyaluronic acid. It can improve skin nutrition metabolism, make skin soft, smooth, and wrinkle-free, increase elasticity, prevent aging, and is a good permeability while moisturizing. Skin absorption enhancer. Used in conjunction with other nutritional ingredients, it can have a more ideal effect of promoting nutrient absorption.

Hyaluronic acid has a special water-retaining effect and is the most moisturizing substance found in nature so far. It is called an ideal natural moisturizing factor (Natural moisturizing factor, NMF, for example, 2% pure hyaluronic acid aqueous solution can firmly Retain 98% moisture.

 

 

What is the difference between hyaluronic acid and sodium hyaluronate?

The two are used in the cosmetics industry, and both mainly have moisturizing functions. The specific difference is that hyaluronic acid is an acid, and sodium hyaluronate is a salt. The sodium content is more stable. Adding sodium will become a non-Newtonian fluid. It is very good for exfoliating. Hyaluronic acid is a holy product for moisturizing. There is a term you should know, that is hyaluronic acid, which belongs to hyaluronic acid.

• The main function of hyaluronic acid:

Biochemical drugs with high clinical value are widely used in various ophthalmic operations, such as lens implantation, corneal transplantation, and anti-glaucoma surgery. It is also used to treat arthritis and accelerate wound healing. When used in cosmetics, it can play a unique role in protecting the skin, keeping the skin moisturized, smooth, delicate, soft, and elastic, and has the functions of anti-wrinkle, anti-wrinkle, beauty care, and restoration of skin physiological functions.

• The main function of sodium hyaluronate:

Widely used in the high-end cosmetics industry for dry eye syndrome. Like hyaluronic acid, sodium hyaluronate can hold up to 1,000 times its weight in water, but this form can penetrate deep into the skin and is more stable in beauty formulations (meaning it lasts a long time). The appearance of sodium hyaluronate can be roughly understood as fibrous or creamy powder, which often appears in moisturizers and essence products. As a humectant, sodium hyaluronate works by drawing moisture from the environment and the underlying layers of the skin into the epidermis. Is a common water-absorbing ingredient. Sodium Hyaluronate acts as the skin's reservoir, helping it regulate moisture levels.

Sodium hyaluronate should be among the skincare ingredients you need to look for Sodium hyaluronate has more stability and penetrating power. Because it is in salt form, sodium hyaluronate is a more stable form of hyaluronic acid. In addition, sodium hyaluronate molecules are smaller. This means that sodium hyaluronate absorbs more effectively and penetrates deeper into the skin while the moisturizing power of hyaluronic acid acts only on the skin's surface. But objectively speaking, although sodium hyaluronate can penetrate the skin more easily, it does not necessarily mean that its skincare effect is better than that of hyaluronic acid.

Classification of hyaluronic acid

The effects of hyaluronic acid with different molecular weights are very different. According to the molecular weight, hyaluronic acid can be divided into four categories: 1. High molecular weight hyaluronic acid; 2. Medium molecular weight hyaluronic acid; 3. Low molecular weight hyaluronic acid; 4. Oligomeric hyaluronic acid.

◆High molecular weight hyaluronic acid: molecular weight higher than 2000Kda, with good viscoelasticity, lubricity, and moisture retention, can be used in ophthalmic and orthopedic surgery products, and cosmetics, it is an excellent moisturizing agent, forming a protective layer on skin surface film, not absorbed by the skin.

◆Medium molecular weight hyaluronic acid: The molecular weight is between 500KDa and 2000KDa. It is the most widely used and can be used in cosmetics, medicine, and health care products. The main function of cosmetics is moisturizing. It can form a breathable film on the surface of the skin, lock in moisture, prevent moisture from evaporating, and keep moisturizing for a long time.

◆Low molecular weight hyaluronic acid: The molecular weight is between 10KDa and 500KDa. It is easily absorbed by the skin and can participate in the internal metabolism of the skin. It has certain effects in anti-inflammation, promoting wound healing, and anti-aging. Poor ability to prevent moisture evaporation.

◆Oligomeric hyaluronic acid: Hyaluronic acid molecules with a molecular weight of less than 10KDa, that is, less than 50 monosaccharide structures, and a degree of polymerization of less than 25, can penetrate the dermis, inhibit the release of inflammatory factors, and relieve the sensitive state caused by various factors. Scavenge free radicals, repair epidermal cells and fibroblast damage, accelerate tissue healing, promote keratinocyte proliferation, and improve skin barrier function.

Benefits

1. Moisturizing

On the one hand, sodium hyaluronate is an inherent endogenous substance of the skin. The use of cosmetics containing sodium hyaluronate can supplement the endogenous sodium hyaluronate of the skin, and promote the supply of skin nutrients and the excretion of waste, thereby preventing skin aging and maintaining skin. Skin plays a role in beautifying and nourishing the skin. On the other hand, studies have shown that regardless of the relative humidity of the external environment, sodium hyaluronate has high water absorption and moisturizing properties, and is known as an ideal natural moisturizing factor.

2. Prevention and repair of skin damage

 Sodium hyaluronate can protect skin keratinocytes from the damage caused by ultraviolet radiation. In sunscreen, and skin care products, sodium hyaluronate is mixed with ultraviolet absorbers to have a synergistic effect. At the same time, sodium hyaluronate can promote the proliferation and differentiation of epidermal cells and scavenge oxygen free radicals, promote the regeneration of damaged skin, and repair skin damage caused by ultraviolet rays. Therefore, sodium hyaluronate has dual functions, which can not only reduce the damage of ultraviolet rays to the skin but also repair the damage to the skin.

3. Lubrication and film-forming properties

pure hyaluronic acid powder is a high-molecular polymer with strong lubricating and film-forming properties. Skin care products containing sodium hyaluronate have an obvious lubricating feeling and good hand feeling when applied. After being applied to the skin, a thin film can be formed on the surface of the skin, making the skin feel smooth and moist, and protecting the skin. Hair care products containing sodium hyaluronate can form a thin film on the surface of the hair, which has the functions of moisturizing, lubricating, hair care, and eliminating static electricity, making the hair easy to comb, elegant, and natural.

1. Used as high-grade cosmetic additives, also used in medicine
2. Used as a moisturizer in the ointment, cream, milk, mask, and essence.

(1) Dehydrate the cockscomb with acetone, crush it, soak in distilled water for 24 hours, fully swell, filter, and extract the filter residue with distilled water 3 times, combine the filtrate, add 100g/L (10%) sodium chloride, after dissolving, add an equal volume chloroform, stirred for 3 hours, separated the water phase, and then added 2 times the volume of 95% ethanol to precipitate hyaluronic acid, dehydrated, and dried to obtain a crude product.
 

(2) Cockscomb [acetone] → dehydrated and crushed cockscomb [distilled water] → [24h] filtrate [NaCl, chloroform] → water phase [95% ethanol] → hyaluronic acid precipitation → crude product
 

(3) Dissolve the crude product in 0.1mol/L sodium chloride solution, adjust the pH to 4.5-5 with dilute hydrochloric acid, add an equal volume of chloroform to stir, and treat twice, adjust the pH of the aqueous phase to 7.5 with NaOH solution, add pronase Incubate at 37°C for 24 hours, treat the enzymatic solution with chloroform 2-3 times, add an equal volume of 10g/L (1%) cetylpyridinium chloride solution to the water phase, let it settle, add 0.4mol/L sodium chloride to the precipitate The solution was stirred and dissociated, centrifuged, and the supernatant was collected, repeatedly precipitated with 3 times the volume of 95% ethanol, dehydrated, and dried to obtain the fine product.
 

(4) Crude product [0.1mol/L NaCl] → solution [dilute HCl, chloroform] → [pH4.5] aqueous phase [NaOH, mycoproteinase] → [pH7.5, 37°C, 24h] enzymatic hydrolysis solution [ Chloroform] → water phase [cetylpyridinium chloride] → precipitation [NaCl] → supernatant [95% ethanol] → precipitation → refined product

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