Rabdosia Rubescens Extract

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Products Description

Rabdosia Rubescens Extract is a natural organic compound extracted from the plant Oridonium. Oridonin, also known as prolongin, is a fragrant tea plant from the Lamiaceae A kind of kaurene diterpenoid compound extracted from the leaves of the plant Rubescens genus, has heat-clearing and detoxifying, anti-inflammatory and analgesic effects, invigorating the stomach and activating blood circulation, and good anti-tumor activity. Various cell lines such as breast cancer have inhibitory effects.

 

 

 

 

Sources of Oridonin

Dongling grass is the dry aboveground part of Rabdosia rubescens (Hemsl.) Hara, a plant in the Labiatae family. It is also known as Rubesia rubescens (Hemsl.) Hara, and is mainly distributed in the Yellow River. The basin and the vast areas to the south are mainly produced in Henan Province.

 

The 2020 edition of "Chinese Pharmacopoeia" records that it tastes bitter, sweet, and slightly cold in nature; it belongs to the lung, stomach, and liver meridians; it has the effects of clearing away heat and detoxification, promoting blood circulation and relieving pain. Clinically, it is mainly used to treat sore throat, tonsillitis, snake bites and esophageal cancer, and other diseases. It was first seen in "Materia Medica for Relief of Famines". It has been used by local folks in Jiyuan to treat esophageal cancer for nearly 40 years.

 

Physical and chemical properties

Common Name	Oridonin	Flash Point	215.0±23.6 °C
CAS Number	28957-04-2	Molecular Weight	364.433
Density	1.4±0.1 g/cm3	Boiling Point	599.8±50.0 °C at 760 mmHg
Molecular Formula	C20H28O6	Melting Point	248-250ºC

 

1. Skin care effect: Oridonin is widely used in skincare products, which can help improve skin quality, brighten skin tone, moisturize, and reduce the appearance of fine lines and wrinkles. Oridonin can promote the proliferation and repair of skin cells and accelerate the wound-healing process. It also helps boost the production of collagen and elastin fibers, improving skin elasticity and firmness.

2. Anti-tumor effect
The anti-tumor effect is the most important pharmacological effect of Rubescens, and Rubescensin A and Rubescensin B are diterpene components isolated from Rubescens oriolis, which have anticancer activities against various tumors.
 

3. Antibacterial and anti-inflammatory effects
The most important anti-inflammatory active ingredient of Rubescens oridonin is Oridonin A and the inhibitory effect of Rubescensin A on the biofilm formation of Staphylococcus aureus can be observed by using the crystal violet staining method and scanning electron microscope. The release amount of strain eDNA inhibits the expression of genes related to Staphylococcus aureus biofilm formation.
 

4. Antioxidant effect
Oridonin has powerful antioxidant activity, which can neutralize free radicals and prevent oxidative stress damage to cells and tissues. This helps slow down the aging process, improves skin quality, and protects general health.

5. Immunity-enhancing effect
The influence of the extraction process of Rubescens japonicus polysaccharide on its immune activity was determined by tetramethylazozolium salt (MTT) colorimetric method, and the polysaccharide extracted by ethanol step-by-step precipitation method had stronger immune activity. Oridonin can regulate the response of the immune system and reduce allergic reactions and allergic symptoms. It has a certain therapeutic effect on allergic dermatitis and other skin allergy diseases.

1. Cosmetics: Applied in cosmetics, it can have anti-oxidation, moisturizing, and repairing effects, and delay skin aging.

2. Drugs: as drug raw materials, they can be used for the prevention and treatment of diseases, such as anti-inflammatory, anti-tumor, hypoglycemic, and other aspects.

3. Health care product: As a raw material of health care products, it has the functions of enhancing immunity, anti-fatigue, and regulating intestinal function.

1. Cosmetics field:

Facial skin care products: Oridonin powder with a concentration of 0.1%-2% is usually recommended. The specific use concentration can be adjusted according to the product type and target effect. For example, products such as creams, lotions, and essences can use lower concentrations, while special skin care products such as masks can use higher concentrations.

Body care products: For body lotion, body cream, and other products, it is generally recommended to use oridonin powder with a concentration of 0.5%-2%.

Sunscreen products: For sunscreen, sunscreen lotion, and other products, it is recommended to use Rubescensin A powder at a concentration of 0.5%-2% to provide additional antioxidant and anti-inflammatory effects. Note: The above recommended dosage is for reference only, and the specific dosage should follow relevant regulations and safety standards, and be reasonably adjusted according to the nature and composition of the product.

2. Pharmaceutical field:
Traditional Chinese medicine preparations: For traditional Chinese medicine preparations, Rubescensin A can be used as one of the active ingredients in dosage forms. The specific dosage should be adjusted according to the needs of the formulation and clinical research. The dosage used in traditional Chinese medicine preparations can be referred to in accordance with relevant pharmacopeias or literature.

Drug development: For the development of oridonin as a single drug ingredient, the recommended dosage range is 100-200 mg per day orally. However, the specific dosage should be determined according to clinical trials and research, and follow the relevant regulations and standards for drug development.
It should be noted that the above-recommended dosage is for reference only. When using Rubescensin A powder, it is recommended to conduct research and development and preparation under professional guidance and follow relevant regulations and safety standards.

Cosmetics field reference formula:

• Brightening Cream:

Oridonin powder: 0.5%
Squalane: 2%
Glycerin: 3%
Vitamin E: 0.2%
Sodium Hyaluronate: 0.2%
Plant extracts (such as arbutin, licorice extract, etc.): appropriate amount
Essential oils (such as lavender essential oil, rose essential oil, etc.): Appropriate amount
Emulsifiers, preservatives, stabilizers, etc.: appropriate amount
Lipid phase (such as water phase, oil phase, emulsifier, etc.): appropriate amount Note: The composition can be adjusted according to specific needs.

• Anti-Acne Repair Mask:

Oridonin A powder: 2%
Bentonite: 10%
Hydrolyzed Collagen: 2%
Potassium sorbate: 1%
Aloe Vera Extract: 3%
Green Tea Extract: 1%
Sodium hyaluronate: 0.5%
Peppermint essential oil: 0.2%
Emulsifiers, preservatives, stabilizers, etc.: appropriate amount
Water phase, oil phase, emulsifier equal: appropriate amount Note: The composition can be adjusted according to specific needs.

Reference formula in the pharmaceutical field:

• Anti-inflammatory cream for external use:

Oridonin A powder: 1%
Rehmannia glutinosa extract: 5%
Gentiana extract: 2%
Rhizoma Cyperi Extract: 1%
Musk: 0.1%
Excipients (such as white wax, liquid paraffin, etc.): Appropriate amount Note: Ingredients and contents can be adjusted according to diseases and indications.

• Anti-allergy oral tablets:

Oridonin A powder: 50mg
Bupleurum extract: 20mg
Sophora flavescens extract: 10mg
Purslane extract: 10mg
Excipients (such as starch, microcrystalline cellulose, etc.): Appropriate amount Note: The above formula is only an example, and the specific dosage and ingredients should be adjusted according to the disease and clinical needs.
Please note that when formulating and using formulas, relevant regulations, and safety standards should be followed and carried out under qualified professional guidance.

Acute toxicity studies: Multiple acute toxicity studies have shown that at appropriate doses, Rubescensia extract and Rubescensin A powder have no obvious acute toxicity. These studies usually use oral or skin contact with experimental animals to observe indicators such as behavior, physiological parameters, and histopathological changes, and no serious adverse reactions have occurred.

Chronic toxicity study: Chronic toxicity study shows that long-term use of appropriate amounts of Rubescens grass extract and Rubescensin A has no obvious adverse effects on various physiological indicators and tissues and organs of animals.

Safe dose determination: Several studies have established safe dose ranges for Rubescensia extract and Rubescensin A. For example, a retrospective study found no significant adverse events in the cardiovascular, nervous, and muscular systems at daily doses of 200-600 mg of oridonium extract.

Clinical trial safety: Some international clinical trials have also confirmed the relative safety of Rubescensia extract and Rubescensin A. In these trials, participants received various doses of oridonium extract, and there were no significant adverse effects or serious safety concerns.

It should be noted that the research results may have certain deviations and limitations. In addition, the safety of Rubescensia extract and Rubescensin A needs further in-depth research and monitoring.
In general, international studies have shown that moderate use of Oridonium extract and Oridonin A powder products have good safety to a certain extent.

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