Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of alpha gpc powder in China. Please feel free to wholesale high quality alpha gpc powder for sale here from our factory. For price consultation, contact us.
Alpha GPC Powder supplier / manufacturer
Alpha GPC Powder (Alpha-Glycerophosphocholine)-also known as glycerophosphocholine or L-α-glycerophosphocholine-is a choline-containing compound that occurs naturally in human cells and neural tissue. It serves as a key intermediate in phospholipid metabolism and is composed of a choline group linked to a glycerophosphate structure.
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As a professional manufacturer of Alpha-GPC powder, KINTAIBIO® offers both standard and microencapsulated forms to meet the raw material requirements for nutritional supplements, functional foods, and pharmaceutical preparations. Our standard Alpha-GPC powder is available in 50% and 99% concentrations. The 99% high-purity grade is ideal for product development requiring precise active ingredient content and consistent formulation, while the 50% grade offers flexibility for formulations with different choline content requirements.
Additionally, we provide microencapsulated Alpha-GPC powder with an active ingredient content of up to 50%. Microencapsulation improves the material's resistance to moisture absorption and enhances powder flowability, thereby mitigating handling issues caused by environmental humidity during processing and storage. Please note that the specific water solubility, release characteristics, and stability of the microencapsulated product depend on the encapsulation materials and process design used; we can provide customized specifications tailored to individual client needs.
- Alpha-GPC Structure: Its molecular structure contains both a hydrophilic choline group and a glycerophosphate group, which confer excellent hydrophilicity and water solubility. As a source of choline, Alpha-GPC provides the body with this essential nutrient-a key precursor for the synthesis of the neurotransmitter acetylcholine (ACh)-while also participating in the synthesis and metabolism of phospholipids within cell membranes.
- Alpha-GPC Mechanism of Action: Once in the body, Alpha-GPC contributes to the supply and utilization of choline. Catalyzed by the enzyme choline acetyltransferase (ChAT), choline combines with acetyl-CoA to produce acetylcholine, which facilitates neural signaling. Furthermore, the choline provided by Alpha-GPC is involved in the biosynthesis of cell membrane phospholipids, such as phosphatidylcholine, playing a vital role in maintaining cell membrane structure and proper neuronal function.
- Alpha-GPC Bioavailability: As a water-soluble choline compound, Alpha GPC Powder exhibits favorable gastrointestinal absorption. Following absorption, it enters the body's choline metabolic pathways, serving as a substrate for the synthesis of acetylcholine and phospholipids. Compared to some other choline sources, Alpha-GPC offers a higher choline content and distinct metabolic characteristics, making it a subject of significant interest in the development of products for brain health, cognitive nutrition, and sports nutrition.
Solubility of α-GPC 50% powder : 5 g dissolves in 50 ml of water
- Alpha-GPC Solubility: Alpha-GPC powder is highly soluble in water, as well as in methanol and ethanol, while showing low solubility in chloroform, diethyl ether, and oils. Because it lacks distinct characteristic absorption peaks in the ultraviolet-visible (UV-Vis) spectrum, its content is typically determined using chromatographic methods-such as high-performance liquid chromatography (HPLC) coupled with an evaporative light-scattering detector (ELSD) or a refractive index detector (RID).
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The primary advantages of Alpha-GPC include its well-defined chemical structure, excellent water solubility, efficacy as a choline source, and broad versatility in various formulations. Please feel free to contact us at sales@kintaibio.com for further information about this product.
COA Of Alpha GPC Powder
what is alpha gPC good for ? / Alpha GPC Powder benefits
Alpha GPC benefits for men
Alpha-GPC contributes to choline metabolism, providing nutritional support for the synthesis of neurotransmitters and the proper functioning of the nervous system. Research suggests that short-term supplementation with Alpha-GPC may help improve performance in healthy men on certain cognitive tasks-specifically those involving attentional control and the management of cognitive interference. However, it cannot be concluded from this that Alpha-GPC directly increases testosterone levels, growth hormone production, or physical strength in men.
Overall, given its role in supplying choline and its involvement in the synthesis of acetylcholine, Alpha GPC Powder serves as an evidence-based ingredient for the formulation of products focused on cognitive health, focus, and sports nutrition. It is particularly well-suited for nutritional supplements designed for men who are interested in supporting brain health, daily cognitive performance, and mental focus during exercise or training.
Alpha GPC for depression
The potential link between Alpha-GPC (alpha-glycerylphosphorylcholine) and monoaminergic neurotransmitter systems-such as those involving dopamine and serotonin-has drawn attention in research concerning mood regulation, motivation, and psychological states. While some findings suggest that Alpha-GPC may play a role in modulating motivation and certain emotional states in healthy individuals, there is currently insufficient clinical evidence to conclude that it can directly alleviate anxiety, treat anxiety disorders, or function as an anxiolytic agent.
In terms of its mechanism of action, acetylcholine and other neurotransmitter systems collectively participate in complex processes that regulate mood and behavior. However, the specific impact of Alpha GPC Powder on these neurotransmitter systems, as well as its relationship with anxiety symptoms, requires further investigation through randomized controlled clinical trials.
Alpha GPC brain benefits
Alpha-GPC (alpha-glycerophosphocholine) plays a significant role in the synthesis of neurotransmitters in the brain, the metabolism of phospholipids in neuronal cell membranes, and the maintenance of normal neurological function. Acetylcholine is involved in neural processes such as learning, memory, attention, and information processing. Furthermore, the choline provided by Alpha-GPC contributes to the synthesis of phospholipids-such as phosphatidylcholine-which are essential for the structural integrity and proper function of neuronal cell membranes. Consequently, Alpha-GPC is of research interest in the fields of brain health, memory support, and cognitive nutrition.
One study has provided clinical insight into the potential role of Alpha-GPC in the recovery of cognitive function following cerebrovascular events; however, this alone is insufficient to establish its efficacy as a treatment for stroke or cerebral ischemia. Overall, given its physiological involvement in choline metabolism, acetylcholine synthesis, and the metabolism of neuronal membrane phospholipids,Alpha GPC Powder holds research value for the development of products focused on memory support, cognitive nutrition, and brain health.
- Alpha GPC for muscle growth : Research on Alpha-GPC in the context of muscle growth has primarily focused on acetylcholine synthesis, neuromuscular signaling, and power output during exercise. One study found that Alpha-GPC supplementation led to significant changes in post-resistance-training growth hormone peaks and peak bench press strength. However, this study had a small sample size and did not directly measure long-term increases in muscle cross-sectional area or muscle mass. Consequently, the value of Alpha-GPC in sports nutrition formulations lies primarily in its role as a source of choline and its potential for supporting neuromuscular function.
- Alpha GPC weight loss : The potential link between Alpha-GPC and weight management primarily stems from research into choline metabolism and fat oxidation. Studies on the role of glycerophosphocholine (GPC) in promoting growth hormone secretion and fat oxidation in young adults have shown that GPC intake leads to an increase in plasma free choline and growth hormone levels. Concurrently, changes were observed in several metabolic markers associated with fat oxidation-specifically free fatty acids, acetoacetate, and β-hydroxybutyrate. These findings provide preliminary evidence for a relationship between GPC and short-term lipid metabolism; consequently, Alpha GPC Powder may serve as an investigational ingredient in sports nutrition and comprehensive metabolic nutritional formulations.
Reference:https://pubmed.ncbi.nlm.nih.gov/39683633/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/
https://pubmed.ncbi.nlm.nih.gov/8030842/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3313098/?utm_source=chatgpt.com
https://pubmed.ncbi.nlm.nih.gov/22673596/
what is Alpha GPC used for ?
Alpha-GPC in Pharmaceutical Applications
Alpha-GPC is primarily researched for its role in providing choline, supporting nervous system function, and promoting cognitive health. Existing clinical literature covers areas such as age-related cognitive changes and cognitive recovery following cerebrovascular events; however, its efficacy in treating neurodegenerative diseases-such as Alzheimer's-requires further, more robust clinical evidence.
Alpha-GPC Supplements
Alpha-GPC is frequently used in the development of products focused on brain health, memory support, attention, and cognitive nutrition. It is often combined with other vitamins, minerals, and botanical extracts to create comprehensive nutritional formulations. Depending on the intended product positioning and desired dosage form, Alpha-GPC raw powder can be processed into capsules, pills, tablets, or gummies to cater to diverse consumer preferences.
Alpha-GPC in Food and Beverages
Thanks to its excellent water solubility, Alpha GPC Powder can be incorporated into liquid nutritional formulations-such as functional beverages and energy drinks-serving as a source of choline for sports nutrition and daily brain-health products.
Alpha-GPC in Sports Nutrition
Alpha-GPC has garnered attention due to the link between choline and neuromuscular signaling, as well as its potential in the context of athletic performance. However, current clinical evidence regarding its ability to enhance strength, promote muscle recovery, or increase growth hormone levels remains inconsistent; therefore, these claims should not be marketed as established benefits.
In summary, Alpha GPC Powder offers versatile formulation adaptability and potential for development into various dosage forms. It serves as a functional, choline-based ingredient for nutritional supplement brands, functional food manufacturers, and pharmaceutical R&D companies, supporting a wide range of product development initiatives.
Alpha GPC side effects,dosage,safety
Alpha GPC Dosage
Currently, regulatory bodies such as the U.S. FDA and the EFSA have not established a unified recommended daily intake for Alpha GPC dietary supplements. Past human clinical studies have utilized short-term supplementation regimens ranging from 315–630 mg per day, while other clinical trials-focused on patients with specific cognitive impairments-have employed medical research protocols involving 800–1,200 mg per day. However, these research-based dosages should not be interpreted as recommendations for daily use by the general consumer.
Alpha GPC Side Effects
Human studies have reported adverse effects including headache, nausea, gastric discomfort, heartburn, insomnia, agitation, and orthostatic hypotension; however, a definitive causal link between these events and the substance itself has not always been established. Excessive choline intake may also be associated with issues such as a "fishy" body odor, vomiting, increased sweating, low blood pressure, and liver toxicity. Consequently, when considering the potential dangers and risks of Alpha GPC, consumers should avoid the long-term, self-directed use of high-dose products-particularly those who are already taking multiple choline-containing supplements.
Alpha GPC Safety
Existing toxicological studies in animals and clinical research in humans generally indicate that Alpha GPC Powder is reasonably well-tolerated under the conditions studied. Nevertheless, this does not imply that all dosages or long-term use are entirely free of risk.
Alpha GPC During Pregnancy
While choline is an essential nutrient for fetal nervous system development and cell membrane formation during pregnancy, its nutritional necessity does not mean that all Alpha GPC products are suitable for pregnant women. Supplementation during pregnancy and breastfeeding should always be undertaken in accordance with professional medical advice.
Alpha GPC legal
In the United States, the FDA completed its evaluation of GRAS Notice GRN 419 in 2012, stating that it had no questions regarding the notifier's intended use of Alpha-GPC as a source of choline in specific conventional foods and beverages at levels ranging from 10 to 100 mg per serving.
In the European market, the European Commission classified L-Alpha-GPC as a "novel food" in a 2024 consultation regarding its regulatory status.
In 2026, the European Food Safety Authority (EFSA) issued a scientific opinion on the safety of L-Alpha-GPC derived from soy phospholipids. The assessment concluded that there are no safety concerns regarding the identity, production process, composition, or specifications of this ingredient, and it affirmed its safety under the conditions of use proposed in the application.
Health Canada has also conducted a safety assessment of L-Alpha-GPC as an ingredient in supplemented foods, recognizing it as a source of choline; the agency requires that such products comply with applicable regulations regarding usage levels and warning labels for supplemented foods.
where to buy Alpha GPC powder ?
If you are looking for a reliable Alpha GPC powder supplier or planning to buy Alpha GPC powder in bulk, KINTAIBIO® offers a range of Alpha GPC ingredients for nutritional supplement, functional food, and pharmaceutical applications. As an experienced Alpha GPC manufacturer, we supply conventional Alpha GPC powder in 50% and 99% specifications, as well as microencapsulated Alpha GPC 50% powder. Our products are suitable for manufacturers developing capsules, tablets, and other nutritional formulations, with options to discuss according to your formulation and processing requirements.
We support wholesale purchasing, sample requests, and OEM/ODM customization. We focus on batch consistency and quality documentation, and can provide COA, Specification, TDS, and MSDS/SDS according to the product and order requirements. Whether you are searching for Alpha GPC for sale, an Alpha GPC 99% powder manufacturer, or a bulk supplier of Alpha GPC, our team can help you evaluate suitable specifications and discuss your sourcing needs.
For the latest Alpha GPC price, bulk order options, or product samples, contact us at sales@kintaibio.com. Share your required purity, order quantity, and intended application, and our team will provide relevant product information and a quotation.
FAQ
Q: When should you take Alpha-GPC?
A: There is currently insufficient human research to definitively state that taking Alpha-GPC in the morning, afternoon, or at any other specific time offers a clear advantage. Because different studies have employed varying dosing schedules and objectives, the timing used in any single study cannot be taken as a universal standard for all consumers. If you are using a commercially available Alpha-GPC supplement, you should follow the instructions on the product label. If you find that taking it affects your energy levels-such as causing overstimulation-or impacts your sleep, you may wish to consult a healthcare professional about adjusting the timing of your dose.
Q: Does Alpha-GPC increase acetylcholine?
A: Alpha-GPC provides choline, which is a precursor for the synthesis of acetylcholine; therefore, it possesses a biochemical basis for supporting cholinergic neurotransmission. Acetylcholine plays a role in processes such as learning, memory, and the transmission of neural signals-which is a key reason why Alpha-GPC is studied in the context of cognitive health. According to an assessment by the EFSA (European Food Safety Authority), oral intake of Alpha-GPC serves as a source of choline that can be utilized in human metabolism.
Q: Can Alpha-GPC be taken with other supplements or medications?
A: Taking Alpha-GPC alongside other choline-containing supplements may lead to excessive intake. If you are already using choline, citicoline (CDP-choline), or other similar nutritional products, you should be mindful of your total choline consumption. Furthermore, individuals who are taking prescription medications, living with chronic conditions, or at risk for cardiovascular or cerebrovascular diseases should not combine Alpha-GPC with their existing treatments without professional guidance. In particular, those who take long-term medication, have blood pressure issues, or have a history of stroke should consult a physician or pharmacist to assess any potential risks.
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