Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of DHEA Dehydroepiandrosterone powder in China. Please feel free to wholesale high quality DHEA Dehydroepiandrosterone powder for sale here from our factory. For price consultation, contact us.
DHEA Dehydroepiandrosterone powder supplier/ manufacturer
As a specialized manufacturer dedicated to the production of high-quality DHEA powder, we fully recognize the critical importance of this endogenous hormone-derived from the human adrenal glands-in maintaining physiological function. Our DHEA Dehydroepiandrosterone Powder is strictly standardized to contain a minimum of 99% dehydroepiandrosterone. Sourced primarily from natural wild yams or soybeans, the product is produced using advanced bio-extraction and synthesis technologies to ensure exceptional purity, stability, and biological activity. We also offer 99% Dehydroepiandrosterone Acetate; as a vital pharmaceutical intermediate, this compound plays a pivotal role in the synthesis of steroid hormone drugs and is widely utilized in the production of medications for prostate cancer, as well as progestogens, estrogens, and anabolic steroids.
| KINTAIBIO® Flow Chart Of DHEA Dehydroepiandrosterone Powder Specification | ||||
| Product Name | Active Ingredients | Specifications | Test Method | |
| DHEA Powder | Dehydroepiandrosterone | 99% | HPLC | |
| DHEA Acetate Powder | Dehydroepiandrosterone Acetate | 99% | HPLC | |
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Numerous studies have demonstrated that DHEA Dehydroepiandrosterone powder offers positive supportive benefits across specific application scenarios: for the elderly, it may improve skin hydration and firmness while reducing age spots; for patients suffering from depression-particularly those with low endogenous DHEA levels-supplementation has proven more effective than a placebo; for postmenopausal women experiencing vaginal atrophy, limited studies suggest it may alleviate symptoms of dryness; furthermore, dehydroepiandrosterone powder is utilized to help enhance physical performance, improve sleep quality, boost memory, modulate immune function, and-in men-to support sexual function by increasing free testosterone levels through the inhibition of testosterone binding to globulin.
Our products offer versatile application across various dosage forms-including tablets, capsules, and bulk powders-and we provide comprehensive support for customized packaging and private labeling to meet our clients' branding needs. Regarding product advantages, KINTAIBIO®'s dHEA powder bulk is manufactured using cutting-edge scientific technologies, with every batch undergoing rigorous quality control to ensure compliance with the highest industry standards. We are committed to providing not merely premium raw materials, but a comprehensive, end-to-end service chain-spanning from R&D to finished DHEA Dehydroepiandrosterone Powder-to help empower healthier lives.Please contact sale@kintaibio.com to request free samples or discuss purchasing matters.
COA Of DHEA Dehydroepiandrosterone Powder
How to make DHEA Dehydroepiandrosterone Powder ?
[Route A]
Dioscorea Plants → Acid Hydrolysis Extraction → Diosgenin → 6-Step Chemical Synthesis (Ring Opening / Oximation / Rearrangement / Hydrolysis) → Crystallization → DHEA (Yield: 40–50%)
[Route B]
Soybean By-products → Mycobacterium Fermentation → 4-AD → Chemical Isomerization → 5-AD → Ketoreductase Reduction → DHEA powder (Overall Yield: 80–95%; Purity: >99%)
[Route C]
Soybean By-products → Mycobacterium Fermentation → 4-AD → Biphasic Fermentation using Engineered Mycobacterium → dehydroepiandrosterone powder (Overall Yield: 50–65%; Purity: 98–99.5%)
what does DHEA Dehydroepiandrosterone Powder do ?
dehydroepiandrosterone hair loss
Drawing upon a specialized understanding of the pathophysiological mechanisms underlying Male Androgenic Alopecia (MAA)-the core of which involves the binding of dihydrotestosterone (DHT) to hair follicle androgen receptors, leading to a shortening of the hair follicle growth phase, follicular miniaturization, and localized inflammatory responses, with genetic factors contributing approximately 80% of the susceptibility-our dehydroepiandrosterone powder, acting as an endogenous hormonal precursor, may-when utilized under scientific guidance-indirectly contribute to the maintenance of the hair follicle microenvironment by modulating the balance of androgen metabolism within the body.
Within the body, DHEA Dehydroepiandrosterone powder can be enzymatically converted into testosterone and DHT; consequently, for individuals predisposed to hair loss, the exogenous supplementation of DHEA requires careful evaluation to avoid exacerbating hair loss through elevated DHT levels. Nevertheless, some studies suggest that DHEA may also exert potential protective effects through mechanisms such as anti-inflammation, the improvement of scalp microcirculation, or the modulation of growth factors; however, as of now, DHEA powder has not been approved by the FDA for the treatment of MAA, and its precise efficacy in preventing hair loss as well as its safety profile currently lack support from large-scale clinical data.
dehydroepiandrosterone and fertility
According to a published study, DHEA demonstrates a clear mechanism of action and offers distinct clinical benefits in improving fertility among older women. The study revealed that, as women age, the decline in oocyte quality is strongly correlated with a significant reduction in the expression levels of genes associated with bioenergetic metabolism. Notably, pure dhea powder
supplementation therapy was found to significantly improve in vitro fertilization (IVF) outcomes in older women: among the group of infertile women receiving DHEA treatment, there was a significant increase in both the total number of Day 3 embryos and the number of high-quality Day 3 embryos, accompanied by improvements in both ongoing pregnancy rates and clinical pregnancy rates.
From a mechanistic perspective, DHEA Dehydroepiandrosterone powder facilitates a shift in aging cells from an anaerobic metabolic mode to an aerobic metabolic mode by enhancing oxidative phosphorylation transport within cumulus cells and increasing mitochondrial oxygen consumption; this process effectively delays the aging of oocytes. Synthesizing the aforementioned evidence, DHEA supplementation therapy provides substantial clinical assistance in boosting fertility for older women by remodeling metabolic pathways and facilitating the metabolic transition from anaerobic to aerobic respiration.
dehydroepiandrosterone weight loss
According to relevant review literature, adrenal hormones-particularly cortisol and dehydroepiandrosterone (DHEA), along with its sulfated form (DHEAS)-play a pivotal role in the pathogenesis and progression of obesity. Among these, cortisol serves as a hormone essential for the body's adaptation to stress; however, when its secretory regulation becomes dysregulated, it is frequently and closely associated with adverse outcomes, such as weight gain.
Notably, the review highlights that the "Cortisol-to-DHEA Ratio" (CDR) serves as a key metric for assessing the functionality of the body's stress response system. Elevated CDR values-often accompanied by diminished levels of DHEA/S-typically portend adverse health outcomes, including an exacerbated degree of physical frailty and immune system dysfunction. It is precisely by leveraging this physiological mechanism of hormonal balance that DHEA Dehydroepiandrosterone powder-distinguished by its unique anti-glucocorticoid properties-is able to mitigate the detrimental effects stemming from cortisol dysregulation, thereby fostering the maintenance of a healthy body weight and promoting healthy aging.
dehydroepiandrosterone dHEA powder benefits for women
One of the currently established clinical applications for dehydroepiandrosterone (DHEA) powder addresses health issues specific to women: specifically, it has been approved-in the form of Intrarosa® (a 6.5 mg vaginal insert)-for the treatment of vaginal atrophy and dyspareunia. This offers an effective topical therapeutic option for women suffering from postmenopausal vaginal dryness and atrophic changes. Furthermore, oral DHEA shows potential for use in the treatment of osteoporosis-a condition with a significantly elevated incidence among postmenopausal women-where appropriate supplementation holds promise for aiding in the improvement of bone density and the reduction of fracture risk.
Concurrently, DHEA Dehydroepiandrosterone powder demonstrates potential therapeutic value in the management of sarcopenia and cachexia, helping to maintain muscle mass and physical function in middle-aged and older women. Moreover, a 10% DHEA ointment formulation holds great promise for promoting skin and muscle regeneration; this carries significant implications for ameliorating age-related changes in women, such as thinning skin, diminished elasticity, and muscle loss.
dehydroepiandrosterone dHEA powder benefits for bodybuilding
Research indicates that DHEA promotes the differentiation and proliferation of osteoblasts, regulates the RANKL/OPG ratio, and inhibits osteoclast formation and bone resorption, thereby exerting a positive influence on bone metabolism. For fitness enthusiasts and individuals engaged in bodybuilding training, a robust skeletal system serves as the foundation for supporting high-intensity strength training, preventing sports-related injuries, and enhancing athletic performance.
In elderly populations characterized by low endogenous androgen levels, dehydroepiandrosterone powder can elevate levels of dehydroepiandrosterone sulfate (DHEA-S) and estradiol, as well as improve bone mineral density-an effect that is particularly pronounced in the ultra-distal radius in women and the femoral neck in men. Furthermore, through mechanisms such as stimulating osteoblast activity and increasing trabecular bone volume, DHEA Dehydroepiandrosterone powder contributes to maintaining skeletal structural integrity; this holds significant importance for individuals who engage in long-term weight-bearing training.
dehydroepiandrosterone dHEA powder benefits for hormone
DHEA and its sulfated form, DHEAS, are primarily synthesized by the adrenal cortex and serve as key precursors for sex steroid hormones; concurrently, they exert a range of physiological functions, including neuroprotection, anti-inflammatory effects, and immune modulation. As individuals age, endogenous DHEA levels undergo a significant decline-a phenomenon often referred to as "adrenopause." This shift is closely correlated with various age-related physiological changes, such as diminished muscle anabolism, reduced bone density, fluctuations in cardiovascular function, and immune dysregulation.
At the level of hormonal regulation, DHEA powder and its sulfated derivative modulate GABA-A, NMDA, and sigma-1 receptors, thereby exhibiting diverse neuroactive properties. These actions contribute to the maintenance of synaptic plasticity and the regulation of emotional stability, while also demonstrating potential therapeutic value in the management of neurodegenerative diseases and depression. For postmenopausal women, DHEA Dehydroepiandrosterone powder has demonstrated definitive benefits in alleviating genitourinary syndrome of menopause; specifically, intravaginal administration effectively improves vaginal health, lubrication, and sexual function, and is considered a safer alternative to systemic estrogen therapy for individuals sensitive to estrogen.
Reference:https://www.ncbi.nlm.nih.gov/books/NBK278957/
https://www.mdpi.com/2072-6643/13/7/2449
https://www.mdpi.com/2079-9721/13/2/42
https://www.mdpi.com/1424-8247/17/9/1186
https://www.mdpi.com/2227-9059/12/12/2780
https://www.mdpi.com/1422-0067/26/17/8568
what is DHEA Dehydroepiandrosterone powder used for ?
Dehydroepiandrosterone Supplement
Dehydroepiandrosterone (DHEA) helps to ameliorate risk factors associated with metabolic syndrome and heart disease-such as reducing abdominal fat and improving insulin resistance. For patients suffering from Systemic Lupus Erythematosus (SLE), taking DHEA supplements may enhance quality of life, decrease the frequency of disease flares, improve cognitive and psychological well-being, and increase bone density. In individuals with adrenal insufficiency-given that DHEA is naturally secreted by the adrenal glands-appropriate supplementation with dehydroepiandrosterone capsules, dehydroepiandrosterone tablets, or dehydroepiandrosterone pills can help alleviate fatigue, improve mood, and enhance overall health status.
Furthermore, the potential applications of DHEA Dehydroepiandrosterone powder extend to areas such as obesity, erectile dysfunction, diminished female libido, and anti-aging. It must be emphasized, however, that the aforementioned applications still require further research to conclusively validate their safety and efficacy. Moreover, conditions such as depression, osteoporosis, and adrenal insufficiency require comprehensive treatment under professional medical supervision and should not be managed solely through the use of dehydroepiandrosterone powder.
DHEA Dehydroepiandrosterone Powder side effects,dosage,safety
Dehydroepiandrosterone Dosage
As a hormonal supplement, DHEA powder is generally considered to fall within a safe and controllable range when taken at a maximum daily dose of 50 mg for a total duration not exceeding two years. However, higher doses or prolonged use may significantly increase the risk of severe adverse reactions.
Dehydroepiandrosterone Side Effects
Common adverse reactions primarily include acne, increased skin oiliness, headaches, and mood swings. For women, particular vigilance is required regarding the potential development of increased facial or body hair (hirsutism) and menstrual cycle irregularities; for men, there is a theoretical risk of abnormal breast enlargement (gynecomastia).Furthermore, DHEA Dehydroepiandrosterone powder may adversely affect biochemical markers-such as lowering levels of "good cholesterol" (High-Density Lipoprotein Cholesterol, HDL-C)-and may exacerbate symptoms in patients with Polycystic Ovary Syndrome (PCOS).
Dehydroepiandrosterone Drug Interactions
DHEA powder may reduce the efficacy of antipsychotics, anticonvulsants, and lithium salts. Concurrent use with estrogens may lead to symptoms of hyperestrogenism, while combined use with SSRI antidepressants may precipitate mania. Additionally, concurrent use with testosterone is not recommended, as it may exacerbate masculinizing effects or estrogen-related side effects.
Dehydroepiandrosterone: Contraindications for Special Populations
The use of Dehydroepiandrosterone powder is strictly contraindicated in the following specific populations: individuals with existing hormone-sensitive cancers or those at risk of developing such cancers; patients with a confirmed diagnosis of Polycystic Ovary Syndrome (PCOS); women who are pregnant or breastfeeding; and patients with a history of severe psychiatric or mood disorders.
All potential users are strongly advised to undergo comprehensive testing-specifically the "six serum sex hormones" panel and liver function tests-at a reputable hospital's endocrinology department prior to deciding to use DHEA Dehydroepiandrosterone powder. Supplementation should be undertaken only under the strict guidance of a licensed physician, who can comprehensively assess the necessity and risks involved, and with regular monitoring of hormone levels and liver enzyme markers.
dehydroepiandrosterone vs Dehydroepiandrosterone acetate
| Category | DHEA | DHEA acetate |
| Specification | 99% Dehydroepiandrosterone | 99% Dehydroepiandrosterone Acetate |
| Molecular formula | C₁₉H₂₈O₂ | C₂₁H₃₀O₃ |
| Appearance | White to off-white crystalline powder | White to off-white crystalline powder |
| Solubility | Moderately fat-soluble | Easily soluble in chloroform and ethyl acetate |
| Stability | Under acidic or alkaline conditions, other reactions tend to occur relatively more readily. | Under alkaline conditions, it readily undergoes hydrolysis to release DHEA. |
| Sources and Preparation Methods | 4-AD is obtained through semi-synthesis of diosgenin or fermentation of soybean phytosterols with mycobacteria to produce 4-AD, followed by chemical-enzymatic or two-step fermentation methods. | Using DHEA as the starting material, acetylation is carried out in the presence of a catalyst using acetic anhydride or acetyl chloride; alternatively, it can be efficiently synthesized through an enzymatic method-such as the ketone reductase-catalyzed reduction of 4-AD-combined with a chemical acetylation step. |
| Main Applications | Dietary Supplements or Hormone Precursors: To ameliorate age-related decline in endocrine function, assist with fertility in older women, support skeletal health, and regulate mood and immune function, among other benefits. | Pharmaceutical Intermediates: Used in the synthesis of the anti-prostate cancer drug Abiraterone Acetate, as well as progestogens, estrogens, anabolic steroids, and similar compounds; in laboratory research, they serve as tool compounds for investigating the physiological roles of androgen precursors. |
| Usability and Security | May be used directly as a supplement under the guidance of a physician; contraindicated for specific populations (e.g., individuals with Polycystic Ovary Syndrome, hormone-sensitive cancers, or pregnant women). | Not intended for direct use as a dietary supplement; strictly for use as a raw material for pharmaceutical synthesis or as a research reagent. Exercise appropriate protective measures during handling; store in a cool, dry place, and avoid contact with strong bases to prevent hydrolysis. |
where to buy DHEA Dehydroepiandrosterone powder ?
If you are seeking a high-quality source of DHEA, KINTAIBIO®-as a professional manufacturer-offers you a reliable procurement channel. You can buy Dehydroepiandrosterone powder directly through our official platform; the product we supply consists of 99% high-purity DHEA Dehydroepiandrosterone Powder, produced using cutting-edge technology and subjected to rigorous quality control.
Whether you intend to buy Dehydroepiandrosterone for use in tablets, capsules, or bulk powder processing, we can provide customized packaging and branding services tailored to your specific requirements. Our DHEA bulk powder's key advantages lie in its high purity, batch-to-batch consistency, and full traceability; our corporate strengths are reflected in our comprehensive quality control system and professional after-sales support. By choosing us, you choose peace of mind and uncompromising quality. For more information regarding our Dehydroepiandrosterone powder or to place an order, please contact our sales team.
★If you are interested in our Bulk DHEA Powder or have any questions, you can click our link below or contact our email:sales@kintaibio.com directly. We will have the most professional business personnel to contact you!
FAQ
Q: What is the difference between DHEA and DHEA-S (Dehydroepiandrosterone Sulfate)?
A: HEA (dehydroepiandrosterone) and DHEA-S (dehydroepiandrosterone sulfate) are two homologous and interconvertible hormonal forms found in the human body; however, they differ substantially in terms of their physiological functions and practical applications. DHEA is the biologically active form secreted by the adrenal glands; it features a free hydroxyl group at the C-3 position, possesses a short half-life (lasting only a few hours), and is relatively unstable in nature. It serves as the direct precursor to the body's sex hormones (testosterone and estrogen) and is the active form typically utilized as the raw material in dietary supplements. Conversely, DHEA-S represents the stable storage and transport form of DHEA, generated through the sulfation of the hydroxyl group at the C-3 position. It boasts a longer half-life (approximately 7 to 10 hours), circulates in the bloodstream at concentrations hundreds of times higher than those of DHEA, and constitutes the predominant form of DHEA present within the body. As physiological needs dictate, the human body can utilize desulfatase enzymes to convert DHEA-S back into active DHEA, which is then further metabolized into sex hormones. In the contexts of diagnostic testing and clinical application, DHEA-S is frequently employed as a clinical biomarker due to its stable plasma concentrations, which accurately reflect the long-term functional reserve of the adrenal cortex; conversely, DHEA-serving as the direct, active form utilized in supplementation-can rapidly elevate the body's endogenous DHEA levels following administration.
Q: In which specific products and fields can DHEA powder be utilized?
A: s a key precursor to sex hormones within the body, DHEA finds extensive application across various sectors, including dietary supplements, pharmaceutical intermediates, and functional foods. In the realm of dietary supplements, DHEA primarily addresses age-related health concerns; given that the body's natural DHEA levels peak in early adulthood and subsequently decline with age, exogenous DHEA supplementation is employed to mitigate age-related declines in endocrine function, support fertility in older women, promote bone health, alleviate genitourinary syndrome of menopause, and help regulate mood and immune function. In the pharmaceutical sector, DHEA serves as a critical starting material for the synthesis of numerous steroidal hormone medications; notably, its derivative-Dehydroepiandrosterone acetate-acts as a core synthetic intermediate in the production of the prostate cancer drug Abiraterone Acetate. The primary target consumer groups include: middle-aged and elderly individuals focused on anti-aging and maintaining physical vitality; older women attempting to conceive who seek to improve ovarian function; postmenopausal women concerned with bone health; and athletes engaged in sports, fitness, and bodybuilding training. We are able to provide customized product specifications and technical support tailored to your specific product positioning-whether it be high-end health supplements, clinical nutritional products, sports supplements, or pharmaceutical raw materials.
Q: What is the purity of the DHEA powder you supply, and what analytical method is used to verify it? What is the dehydroepiandrosterone natural sources?
A: We supply DHEA powder with a specification of 99% purity (determined via HPLC); quantitative analysis is conducted in accordance with the internationally recognized High-Performance Liquid Chromatography (HPLC) method. Regarding raw material sourcing, DHEA can be produced via several commercial pathways. Two primary process routes are predominantly utilized: The first is the microbial fermentation route using plant sterols-this method employs soybean processing byproducts (such as soybean deodorizer distillates) as raw materials; through fermentation using Mycobacterium species, these are converted into 4-androstenedione (4-AD), which is then synthesized into DHEA via either a chemo-enzymatic process or a two-step fermentation process. The second is the traditional semi-synthesis route utilizing diosgenin-this method utilizes the rhizomes of Dioscorea (yam) plants as raw materials; diosgenin is extracted via acid hydrolysis and subsequently converted into DHEA through a six-step chemical reaction sequence. It is worth noting that after diosgenin is chemically converted into DHEA in a laboratory setting, any residual diosgenin is completely eliminated from the product, leaving only DHEA itself; therefore, consuming the fully converted DHEA powder does not result in the ingestion of diosgenin.
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