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Avenanthramides Oat Extract supplier
Kintai Avenanthramides Oat Extract is a natural alkaloid extracted from oats. Its main ingredient is dihydroavenate alkaloid C, which has multiple effects such as anti-inflammatory, soothing, and antipruritic. It is currently widely used as a daily chemical raw material, especially in products with anti-irritation and antipruritic effects. Such as creams, lotions, essences, emulsions, and masks, the recommended dosage is usually: 0.05~2.0%. The pH range is recommended: 5.5-7.5. KINTAI's main production specifications are 98%, and it is soluble in most polyols, glycerin, surfactants, ethanol, etc., and is divided into two types: water-soluble and alcohol-soluble.
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Efficacy of Avenanthramides
1 Antioxidant activity
The antioxidant activity of avenate alkaloids is higher than that of caffeic acid and ferulic acid. The antioxidant capacity is from high to low in the order of avenate alkaloids > avenate alkaloids B > avenate alkaloids C. Avenate alkaloid extracts can not only enhance the antioxidant enzyme activity of liver tissue, reduce the content of malondialdehyde (MDA), significantly reduce serum cholesterol and low-density cholesterol levels, but also increase the expression levels of SOD enzymes, glutathione enzymes and lipoprotein lipase genes in liver tissue.
2 Anti-inflammatory effect
Avenate alkaloids have potent anti-inflammatory and antipruritic properties and are one of the natural ingredients of non-steroidal anti-inflammatory drugs. Avenate alkaloids can mediate cellular inflammatory responses through interactions with cytokines and signaling pathways. At present, a drug derived from avenate alkaloids, dihydroxyavenate alkaloids (DHAvn), is used to treat histamine-related skin diseases such as itching, erythema, blisters, sunburn, eczema, etc. Histamine signal transduction is inhibited by avenate alkaloids, thereby achieving anti-inflammatory and antipruritic effects.
Generally speaking, the itching degree of human skin is not as severe as that of mice directly applying the histamine-producing compound 48/80. After applying oat alkaloids to human skin, the itching sensation is significantly improved within 3 to 5 minutes. Therefore, oat alkaloids have strong antipruritic and soothing activity.
Related studies have shown that 30ppm oat alkaloids have a significant antihistamine effect. Within 30 minutes, the degree of itching, erythema and edema is reduced by more than 50%; after 90 minutes, itching is basically not felt, and erythema and edema are basically gone.
3 Hypolipidemic activity
The effect of oat alkaloid extract on the expression of LPL mRNA in mouse liver was studied. It was found that compared with the normal group, the expression of LPL mRNA in the aging group mice was reduced, and the difference was not significant. Compared with the aging group, different doses of oat alkaloids can increase the expression of LPL mRNA. The difference was significant (P<0.05), indicating that oat alkaloid extract can increase the expression of LPL mRNA in mouse liver and thus prevent atherosclerosis .
4 Inhibit cell proliferation activity
Avenanthramides Oat Extract have the effect of inhibiting the proliferation of vascular smooth muscle cells (VSMCs), preventing the occurrence of restenosis after atherosclerosis and angioplasty, and can be used clinically to avoid the occurrence of restenosis after percutaneous transluminal coronary angioplasty. Oat alkaloids can significantly inhibit the growth of colon cancer, breast cancer and prostate cancer cells, especially the most obvious inhibitory effect on colon cancer proliferation cells. In the experiment, after using oat alkaloids to treat human cloned colon adenocarcinoma (Caco-2) cells, it was found that natural oat alkaloids can effectively inhibit the proliferation of cancer cells during the growth period.
Safety of Avenanthramides
Experts have studied the functional effects of Avenanthramides Oat Extract in animals. Mice were fed feeds without or with 0.1g/kg of dihydrooat alkaloids to see how this substance regulates the balance of oxidation and antioxidant in the mouse's internal tissues. In addition, after 50 days of feeding the mice, the two groups of mice were divided into exercise and non-exercise groups to study the effects of dihydrooat alkaloids on exercise-induced oxidation in the internal organs and tissues of mice.
The results showed that supplementation with dihydrooat alkaloids had no effect on the production of reactive oxygen species in most tissues, except for reducing the level of reactive oxygen species in the soleus muscle of mice, which indicates that dihydrooat alkaloids do not affect cellular energy metabolism.
Supplementation with dihydrooat alkaloids can increase the activity of superoxide dismutase in thigh muscles, liver, and kidneys, and can increase the activity of glutathione peroxidase in thigh muscles and heart. Exercise can increase muscle and myocardial oxidative stress, increase reactive oxygen species, and accelerate heart, liver and muscle peroxidation. Experiments have found that dihydroavenate alkaloids can relieve muscle reactive oxygen production caused by exercise and reduce fat peroxidation in the heart.
This shows that dihydroavenate alkaloids can be added to the diet as an effective antioxidant.
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Application
The content of natural oat alkaloids in oats is very low, but it has important functions such as strong antioxidant, anti-irritation, lipid-lowering, antipruritic and anti-inflammatory properties, making it widely used in cosmetics, skin care and pharmaceutical industries.
(1) Cosmetics industry
Avenanthramides Oat Extract have good antioxidant and anti-allergic properties, making it an excellent skin protectant. Oat alkaloids have excellent anti-inflammatory and antipruritic activity, making it a good replacement for glucocorticoids and used in various topical skin care products. Kim et al. studied that dihydroavenate acyl anthranilic acid D (DHAvD) can effectively prevent the generation of reactive oxygen species (ROS) and the expression of matrix metalloproteinases (MMP-1 and MMP-3) in skin fibroblasts induced by ultraviolet rays. Symrise, the world's fourth largest daily chemical company, is committed to the ingredient of natural oat alkaloids.
The company's research team launched a patented product, Dihydroavenanthramide D, which is traded under the name SymCalmin. It has also further studied the anti-inflammatory and antipruritic effects of this ingredient and is suitable for use in cosmetic formulations for sensitive skin, dry skin, sunburned skin, itchy skin, aging skin, and anti-dandruff. In cosmetic formulations, oat alkaloid compounds are considered to be an effective multifunctional active ingredient and are widely used in various cosmetic products, such as facial masks, acne removers, mild makeup removers, and anti-dandruff agents.
(2) Pharmaceutical and health care industry
Avns have a range of biological activities, including anti-inflammatory, anti-proliferative, antioxidant, antipruritic and vasodilatory activities. Avns can regulate different signal transduction pathways related to cancer, diabetes, inflammation and cardiovascular disease; it can exert anti-cancer effects by regulating different cell signaling pathways and activating cells, thereby inhibiting the development or progression of cancer. The results of the study suggest that regular consumption of Avns-rich oats may have a preventive effect in many chronic and age-related diseases. For example, these unique oat metabolites can inhibit inflammation, prevent smooth muscle hyperplasia, and relax blood vessels, and are therefore believed to prevent inflammatory diseases. At the same time, Avns play an important role in cardiovascular protection and improve cognitive ability through vasodilation of cerebral blood vessels.
With economic development and the improvement of people's living standards, people are paying more and more attention to the nutritional value and medical and health care functions of oats, and their expectations for oat products are getting higher and higher. And with the gradual discovery of the functional components and health care effects of oat alkaloids, the main direction of oat alkaloid development in the future is as an additive for cosmetics, medicine, and health foods, which has broad application prospects and huge development potential, and its deep processing technology will become increasingly industrialized.
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